| 释义 |
- Interactions
- References
- Further reading
{{Infobox_gene}}Megakaryocyte-associated tyrosine-protein kinase is an enzyme that in humans is encoded by the MATK gene.[1][2][3]The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene.[3] InteractionsMegakaryocyte-associated tyrosine kinase has been shown to interact with CD117[4][5] and TrkA.[6] References1. ^{{cite journal |vauthors=Bennett BD, Cowley S, Jiang S, London R, Deng B, Grabarek J, Groopman JE, Goeddel DV, Avraham H | title = Identification and characterization of a novel tyrosine kinase from megakaryocytes | journal = J Biol Chem | volume = 269 | issue = 2 | pages = 1068–74 |date=February 1994 | pmid = 8288563 | pmc = | doi = }}
2. ^{{cite journal |vauthors=Avraham S, Jiang S, Ota S, Fu Y, Deng B, Dowler LL, White RA, Avraham H | title = Structural and functional studies of the intracellular tyrosine kinase MATK gene and its translated product | journal = J Biol Chem | volume = 270 | issue = 4 | pages = 1833–42 |date=February 1995 | pmid = 7530249 | pmc = | doi =10.1074/jbc.270.4.1833 }}
3. ^1 {{cite web | title = Entrez Gene: MATK megakaryocyte-associated tyrosine kinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4145| accessdate = }}
4. ^{{cite journal |doi=10.1074/jbc.270.16.9661 |last=Jhun |first=B H |authorlink= |author2=Rivnay B |author3=Price D |author4=Avraham H |date=April 1995 |title=The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit |journal=J. Biol. Chem. |volume=270 |issue=16 |pages=9661–6 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 7536744 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
5. ^{{cite journal |doi=10.1074/jbc.272.9.5915 |last=Price |first=D J |authorlink= |author2=Rivnay B |author3=Fu Y |author4=Jiang S |author5=Avraham S |author6=Avraham H |date=February 1997 |title=Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes |journal=J. Biol. Chem. |volume=272 |issue=9 |pages=5915–20 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9038210 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
6. ^{{cite journal |doi=10.1074/jbc.274.21.15059 |last=Yamashita |first=H |authorlink= |author2=Avraham S |author3=Jiang S |author4=Dikic I |author5=Avraham H |date=May 1999 |title=The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells |journal=J. Biol. Chem. |volume=274 |issue=21 |pages=15059–65 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10329710 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Okada M, Nada S, Yamanashi Y, etal |title=CSK: a protein-tyrosine kinase involved in regulation of src family kinases. |journal=J. Biol. Chem. |volume=266 |issue= 36 |pages= 24249–52 |year= 1992 |pmid= 1722201 |doi= }}
- {{cite journal |vauthors=McVicar DW, Lal BK, Lloyd A, etal |title=Molecular cloning of lsk, a carboxyl-terminal src kinase (csk) related gene, expressed in leukocytes. |journal=Oncogene |volume=9 |issue= 7 |pages= 2037–44 |year= 1994 |pmid= 7516063 |doi= }}
- {{cite journal |vauthors=Jhun BH, Rivnay B, Price D, Avraham H |title=The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit. |journal=J. Biol. Chem. |volume=270 |issue= 16 |pages= 9661–6 |year= 1995 |pmid= 7536744 |doi=10.1074/jbc.270.16.9661 }}
- {{cite journal |vauthors=Hamaguchi I, Iwama A, Yamaguchi N, etal |title=Characterization of mouse non-receptor tyrosine kinase gene, HYL. |journal=Oncogene |volume=9 |issue= 11 |pages= 3371–4 |year= 1994 |pmid= 7936664 |doi= }}
- {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal |vauthors=Sakano S, Iwama A, Inazawa J, etal |title=Molecular cloning of a novel non-receptor tyrosine kinase, HYL (hematopoietic consensus tyrosine-lacking kinase). |journal=Oncogene |volume=9 |issue= 4 |pages= 1155–61 |year= 1994 |pmid= 8134117 |doi= }}
- {{cite journal |vauthors=Zrihan-Licht S, Lim J, Keydar I, etal |title=Association of csk-homologous kinase (CHK) (formerly MATK) with HER-2/ErbB-2 in breast cancer cells. |journal=J. Biol. Chem. |volume=272 |issue= 3 |pages= 1856–63 |year= 1997 |pmid= 8999872 |doi=10.1074/jbc.272.3.1856 }}
- {{cite journal |vauthors=Price DJ, Rivnay B, Fu Y, etal |title=Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes. |journal=J. Biol. Chem. |volume=272 |issue= 9 |pages= 5915–20 |year= 1997 |pmid= 9038210 |doi=10.1074/jbc.272.9.5915 }}
- {{cite journal |vauthors=Hirao A, Hamaguchi I, Suda T, Yamaguchi N |title=Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets. |journal=EMBO J. |volume=16 |issue= 9 |pages= 2342–51 |year= 1997 |pmid= 9171348 |doi= 10.1093/emboj/16.9.2342 | pmc=1169835 }}
- {{cite journal |vauthors=Grgurevich S, Linnekin D, Musso T, etal |title=The Csk-like proteins Lsk, Hyl, and Matk represent the same Csk homologous kinase (Chk) and are regulated by stem cell factor in the megakaryoblastic cell line MO7e. |journal=Growth Factors |volume=14 |issue= 2-3 |pages= 103–15 |year= 1997 |pmid= 9255603 |doi=10.3109/08977199709021514 }}
- {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
- {{cite journal |vauthors=Grgurevich S, Mikhael A, McVicar DW |title=The Csk homologous kinase, Chk, binds tyrosine phosphorylated paxillin in human blastic T cells. |journal=Biochem. Biophys. Res. Commun. |volume=256 |issue= 3 |pages= 668–75 |year= 1999 |pmid= 10080957 |doi= 10.1006/bbrc.1999.0398 }}
- {{cite journal |vauthors=Yamashita H, Avraham S, Jiang S, etal |title=The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells. |journal=J. Biol. Chem. |volume=274 |issue= 21 |pages= 15059–65 |year= 1999 |pmid= 10329710 |doi=10.1074/jbc.274.21.15059 }}
- {{cite journal |vauthors=McShan GD, Zagozdzon R, Park SY, etal |title=Csk homologous kinase associates with RAFTK/Pyk2 in breast cancer cells and negatively regulates its activation and breast cancer cell migration. |journal=Int. J. Oncol. |volume=21 |issue= 1 |pages= 197–205 |year= 2002 |pmid= 12063569 |doi= 10.3892/ijo.21.1.197}}
- {{cite journal |vauthors=Kim S, Zagozdzon R, Meisler A, etal |title=Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function in breast cancer. |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 36465–70 |year= 2002 |pmid= 12122014 |doi= 10.1074/jbc.M206018200 }}
- {{cite journal |vauthors=Zagozdzon R, Bougeret C, Fu Y, Avraham HK |title=Overexpression of the Csk homologous kinase facilitates phosphorylation of Akt/PKB in MCF-7 cells. |journal=Int. J. Oncol. |volume=21 |issue= 6 |pages= 1347–52 |year= 2003 |pmid= 12429987 |doi= 10.3892/ijo.21.6.1347}}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
- {{cite journal |vauthors=Mikkola ET, Bergman M |title=Conserved hydrophobicity in the SH2-kinase linker is required for catalytic activity of Csk and CHK. |journal=FEBS Lett. |volume=544 |issue= 1-3 |pages= 11–4 |year= 2003 |pmid= 12782282 |doi=10.1016/S0014-5793(03)00405-8 }}
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