| 词条 | Miotine |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 424730241 | ImageFile = Miotine.png | ImageSize = 200px | IUPACName = [3-[1-(Dimethylamino)ethyl]phenyl] N-methylcarbamate | OtherNames = |Section1={{Chembox Identifiers | CASNo_Ref = {{cascite|correct|??}} | CASNo = 4464-16-8 | PubChem = 46093 | SMILES = CC(C1=CC(=CC=C1)OC(=O)NC)N(C)C | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 41955 | InChI = 1/C12H18N2O2/c1-9(14(3)4)10-6-5-7-11(8-10)16-12(15)13-2/h5-9H,1-4H3,(H,13,15) | InChIKey = KQOUPMYYRQWZLI-UHFFFAOYAX | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C12H18N2O2/c1-9(14(3)4)10-6-5-7-11(8-10)16-12(15)13-2/h5-9H,1-4H3,(H,13,15) | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = KQOUPMYYRQWZLI-UHFFFAOYSA-N | RTECS = | MeSHName = | ChEBI = | KEGG_Ref = {{keggcite|changed|kegg}} | KEGG = C11763 |Section2={{Chembox Properties | C=12 | H=18 | N=2 | O=2 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}Miotine is an anticholinesterase drug. Miotine was the first synthetic carbamate that was used clinically.[1] Unlike the miotine analog neostigmine, it doesn't have a quaternary ammonium group to give it a permanent positive charge. It can exist as an uncharged free base which could allow it to cross the blood–brain barrier and cause unwanted central nervous system (CNS) side effects.[2] References1. ^"http://www.weizmann.ac.il/sb/faculty_pages/Sussman/papers/2002_Bar-On_Biochem.pdf" {{Acetylcholine metabolism and transport modulators}}{{pharma-stub}}2. ^"http://media.wiley.com/product_data/excerpt/72/04700259/0470025972.pdf" 3 : Acetylcholinesterase inhibitors|Carbamates|Phenol ethers |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。