| 释义 |
- Function
- Biotechnology application
- Interactions
- References
- Further reading
{{Infobox_gene}}Macrophage scavenger receptor 1, also known as MSR1, is a protein which in humans is encoded by the MSR1 gene.[1][2]MSR1 has also recently been designated CD204 (cluster of differentiation 204). Function This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. They were thought to be expressed macrophage-specific, but recently shown to be present on different dendritic cells classes, too.[3] The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.[1] Biotechnology application Macrophage scavenger receptor has been shown to mediate adhesion of macrophages and other cell lines to tissue culture plastic.[4] InteractionsMSR1 has been shown to interact with HSPA1A.[5] References 1. ^1 {{cite web | title = Entrez Gene: MSR1 macrophage scavenger receptor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4481| accessdate = }}
2. ^{{cite journal |vauthors=Matsumoto A, Naito M, Itakura H, Ikemoto S, Asaoka H, Hayakawa I, Kanamori H, Aburatani H, Takaku F, Suzuki H | title = Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 87 | issue = 23 | pages = 9133–7 |date=December 1990 | pmid = 2251254 | pmc = 55118 | doi = 10.1073/pnas.87.23.9133| url = | issn = | bibcode = 1990PNAS...87.9133M }}
3. ^{{cite journal |vauthors=Herber DL, Cao W, Nefedova Y, Novitskiy SV, Nagaraj S, Tyurin VA, Corzo A, Cho HI, Celis E, Lennox B, Knight SC, Padhya T, McCaffrey TV, McCaffrey JC, Antonia S, Fishman M, Ferris RL, Kagan VE, Gabrilovich DI | title = Lipid accumulation and dendritic cell dysfunction in cancer | journal = Nat. Med. | volume = 16 | issue = 8 | pages = 880–6 |date=August 2010 | pmid = 20622859 | pmc = 2917488 | doi = 10.1038/nm.2172 | url = | issn = }}
4. ^{{cite journal |vauthors=Robbins AK, Horlick RA | title = Macrophage scavenger receptor confers an adherent phenotype to cells in culture | journal = BioTechniques | volume = 25 | issue = 2 | pages = 240–4 |date=August 1998 | pmid = 9714883 | doi = | url = | issn = }}
5. ^{{cite journal |last=Nakamura |first=Toshinobu |authorlink= |author2=Hinagata Jun-ichi |author3=Tanaka Toshiki |author4=Imanishi Takeshi |author5=Wada Youichiro |author6=Kodama Tatsuhiko |author7=Doi Takefumi |date=Jan 2002 |title=HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors |journal=Biochem. Biophys. Res. Commun. |volume=290 |issue=2 |pages=858–64 |publisher= |location = United States| issn = 0006-291X| pmid = 11785981 |doi = 10.1006/bbrc.2001.6271 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
Further reading {{refbegin | 2}}- {{cite journal |vauthors=Asaoka H, Matsumoto A, Itakura H, Kodama T |title=[Structural and function of the human macrophage scavenger receptor] |journal=Nippon Rinsho |volume=51 |issue= 6 |pages= 1677–83 |year= 1993 |pmid= 8391600 |doi= }}
- {{cite journal |vauthors=Naito M, Suzuki H, Mori T, etal |title=Coexpression of type I and type II human macrophage scavenger receptors in macrophages of various organs and foam cells in atherosclerotic lesions. |journal=Am. J. Pathol. |volume=141 |issue= 3 |pages= 591–9 |year= 1992 |pmid= 1519666 |doi= | pmc=1886699 }}
- {{cite journal |vauthors=Matsumoto A, Naito M, Itakura H, etal |title=Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 23 |pages= 9133–7 |year= 1991 |pmid= 2251254 |doi=10.1073/pnas.87.23.9133 | pmc=55118 |bibcode=1990PNAS...87.9133M }}
- {{cite journal |vauthors=Emi M, Asaoka H, Matsumoto A, etal |title=Structure, organization, and chromosomal mapping of the human macrophage scavenger receptor gene. |journal=J. Biol. Chem. |volume=268 |issue= 3 |pages= 2120–5 |year= 1993 |pmid= 8093617 |doi= }}
- {{cite journal |vauthors=Ashkenas J, Penman M, Vasile E, etal |title=Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors. |journal=J. Lipid Res. |volume=34 |issue= 6 |pages= 983–1000 |year= 1993 |pmid= 8394868 |doi= }}
- {{cite journal |vauthors=Resnick D, Chatterton JE, Schwartz K, etal |title=Structures of class A macrophage scavenger receptors. Electron microscopic study of flexible, multidomain, fibrous proteins and determination of the disulfide bond pattern of the scavenger receptor cysteine-rich domain. |journal=J. Biol. Chem. |volume=271 |issue= 43 |pages= 26924–30 |year= 1996 |pmid= 8900177 |doi=10.1074/jbc.271.43.26924 }}
- {{cite journal |vauthors=Hsu HY, Hajjar DP, Khan KM, Falcone DJ |title=Ligand binding to macrophage scavenger receptor-A induces urokinase-type plasminogen activator expression by a protein kinase-dependent signaling pathway. |journal=J. Biol. Chem. |volume=273 |issue= 2 |pages= 1240–6 |year= 1998 |pmid= 9422792 |doi=10.1074/jbc.273.2.1240 }}
- {{cite journal |vauthors=Gough PJ, Greaves DR, Gordon S |title=A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene generated by alternative splicing blocks modified LDL uptake. |journal=J. Lipid Res. |volume=39 |issue= 3 |pages= 531–43 |year= 1998 |pmid= 9548586 |doi= }}
- {{cite journal |vauthors=Teupser D, Thiery J, Seidel D |title=Alpha-tocopherol down-regulates scavenger receptor activity in macrophages. |journal=Atherosclerosis |volume=144 |issue= 1 |pages= 109–15 |year= 1999 |pmid= 10381284 |doi=10.1016/S0021-9150(99)00040-4 }}
- {{cite journal |vauthors=Nakamura T, Hinagata J, Tanaka T, etal |title=HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors. |journal=Biochem. Biophys. Res. Commun. |volume=290 |issue= 2 |pages= 858–64 |year= 2002 |pmid= 11785981 |doi= 10.1006/bbrc.2001.6271 }}
- {{cite journal |vauthors=Tomokiyo R, Jinnouchi K, Honda M, etal |title=Production, characterization, and interspecies reactivities of monoclonal antibodies against human class A macrophage scavenger receptors. |journal=Atherosclerosis |volume=161 |issue= 1 |pages= 123–32 |year= 2002 |pmid= 11882324 |doi=10.1016/S0021-9150(01)00624-4 }}
- {{cite journal |vauthors=Xu J, Zheng SL, Komiya A, etal |title=Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. |journal=Nat. Genet. |volume=32 |issue= 2 |pages= 321–5 |year= 2002 |pmid= 12244320 |doi= 10.1038/ng994 }}
- {{cite journal |vauthors=Xu J, Zheng SL, Komiya A, etal |title=Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. |journal=Am. J. Hum. Genet. |volume=72 |issue= 1 |pages= 208–12 |year= 2003 |pmid= 12471593 |doi=10.1086/345802 | pmc=378627 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
- {{cite journal |vauthors=Kosswig N, Rice S, Daugherty A, Post SR |title=Class A scavenger receptor-mediated adhesion and internalization require distinct cytoplasmic domains. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34219–25 |year= 2003 |pmid= 12819208 |doi= 10.1074/jbc.M303465200 }}
- {{cite journal |vauthors=Miller DC, Zheng SL, Dunn RL, etal |title=Germ-line mutations of the macrophage scavenger receptor 1 gene: association with prostate cancer risk in African-American men. |journal=Cancer Res. |volume=63 |issue= 13 |pages= 3486–9 |year= 2003 |pmid= 12839931 |doi= }}
- {{cite journal |vauthors=Wang L, McDonnell SK, Cunningham JM, etal |title=No association of germline alteration of MSR1 with prostate cancer risk. |journal=Nat. Genet. |volume=35 |issue= 2 |pages= 128–9 |year= 2003 |pmid= 12958598 |doi= 10.1038/ng1239 }}
- {{cite journal |vauthors=Nupponen NN, Wallén MJ, Ponciano D, etal |title=Mutational analysis of susceptibility genes RNASEL/HPC1, ELAC2/HPC2, and MSR1 in sporadic prostate cancer. |journal=Genes Chromosomes Cancer |volume=39 |issue= 2 |pages= 119–25 |year= 2004 |pmid= 14695991 |doi= 10.1002/gcc.10308 }}
- {{cite journal |vauthors=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance. |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8 | pmc=395752 }}
{{refend}}{{NLM content}}{{Clusters of differentiation}} 2 : Clusters of differentiation|Scavenger receptors |