1. Function

2. Interactions

3. References

4. Further reading

Function

NACA prevents short recently synthesized (i.e., nascent) ribosome-associated polypeptides from inappropriate interactions with cytosolic proteins. NACA binds nascent-polypeptide domains emerging from ribosomes unless it contains a signal peptide which is fully exposed. Depletion of NACA from ribosomes carrying nascent polypeptides allows the signal recognition particle (SRP) to crosslink to polypeptides regardless of whether or not they contain signal peptides or not. In the absence of NACA, proteins lacking signal peptides can be mis-translocated into the endoplasmic reticulum.^[2][4]

The NACA protein is expressed in bone during development and acts as a transcriptional coactivator in conjunction with acidic activators.^[3]

Interactions

NACA has been shown to interact with BTF3, FADD,^[5] C-jun,^[6] and 3 members of taxilin family.^[7]

References

Further reading

• {{cite journal | vauthors=Wiedmann B, Sakai H, Davis TA, Wiedmann M |title=A protein complex required for signal-sequence-specific sorting and translocation. |journal=Nature |volume=370 |issue= 6489 |pages= 434–40 |year= 1994 |pmid= 8047162 |doi= 10.1038/370434a0 }}
• {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
• {{cite journal | vauthors=Yotov WV, St-Arnaud R |title=Mapping of the human gene for the alpha-NAC/1.9.2 (NACA/1.9.2) transcriptional coactivator to Chromosome 12q23-24.1. |journal=Mamm. Genome |volume=7 |issue= 2 |pages= 163–4 |year= 1996 |pmid= 8835540 |doi=10.1007/BF03035343 }}
• {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
• {{cite journal | vauthors=Yotov WV, Moreau A, St-Arnaud R |title=The alpha chain of the nascent polypeptide-associated complex functions as a transcriptional coactivator. |journal=Mol. Cell. Biol. |volume=18 |issue= 3 |pages= 1303–11 |year= 1998 |pmid= 9488445 |doi= 10.1128/MCB.18.3.1303| pmc=108843 }}
• {{cite journal | vauthors=Moreau A, Yotov WV, Glorieux FH, St-Arnaud R |title=Bone-specific expression of the alpha chain of the nascent polypeptide-associated complex, a coactivator potentiating c-Jun-mediated transcription. |journal=Mol. Cell. Biol. |volume=18 |issue= 3 |pages= 1312–21 |year= 1998 |pmid= 9488446 |doi= 10.1128/MCB.18.3.1312| pmc=108844 }}
• {{cite journal | vauthors=Munz B, Wiedmann M, Lochmüller H, Werner S |title=Cloning of novel injury-regulated genes. Implications for an important role of the muscle-specific protein skNAC in muscle repair. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 13305–10 |year= 1999 |pmid= 10224091 |doi=10.1074/jbc.274.19.13305 }}
• {{cite journal | vauthors=Beatrix B, Sakai H, Wiedmann M |title=The alpha and beta subunit of the nascent polypeptide-associated complex have distinct functions. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37838–45 |year= 2001 |pmid= 10982809 |doi= 10.1074/jbc.M006368200 }}
• {{cite journal |vauthors=Zhang QH, Ye M, Wu XY, etal |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200 | pmc=310934 }}
• {{cite journal |vauthors=Sims RJ, Weihe EK, Zhu L, etal |title=m-Bop, a repressor protein essential for cardiogenesis, interacts with skNAC, a heart- and muscle-specific transcription factor. |journal=J. Biol. Chem. |volume=277 |issue= 29 |pages= 26524–9 |year= 2002 |pmid= 12011100 |doi= 10.1074/jbc.M204121200 }}
• {{cite journal | vauthors=Kim SH, Shim KS, Lubec G |title=Human brain nascent polypeptide-associated complex alpha subunit is decreased in patients with Alzheimer' s disease and Down syndrome. |journal=J. Investig. Med. |volume=50 |issue= 4 |pages= 293–301 |year= 2002 |pmid= 12109594 |doi=10.2310/6650.2002.33287 }}
• {{cite journal |vauthors=Behrends U, Jandl T, Golbeck A, etal |title=Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library. |journal=Int. J. Cancer |volume=100 |issue= 6 |pages= 669–77 |year= 2002 |pmid= 12209604 |doi= 10.1002/ijc.10550 }}
• {{cite journal |vauthors=Mossabeb R, Seiberler S, Mittermann I, etal |title=Characterization of a novel isoform of alpha-nascent polypeptide-associated complex as IgE-defined autoantigen. |journal=J. Invest. Dermatol. |volume=119 |issue= 4 |pages= 820–9 |year= 2002 |pmid= 12406326 |doi= 10.1046/j.1523-1747.2002.00518.x }}
• {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
• {{cite journal |vauthors=Stilo R, Liguoro D, di Jeso B, etal |title=The alpha-chain of the nascent polypeptide-associated complex binds to and regulates FADD function. |journal=Biochem. Biophys. Res. Commun. |volume=303 |issue= 4 |pages= 1034–41 |year= 2003 |pmid= 12684039 |doi=10.1016/S0006-291X(03)00487-X }}
• {{cite journal |vauthors=Papachristou DJ, Batistatou A, Sykiotis GP, etal |title=Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas. |journal=Bone |volume=32 |issue= 4 |pages= 364–71 |year= 2003 |pmid= 12689679 |doi=10.1016/S8756-3282(03)00026-7 }}
• {{cite journal | vauthors=Hämmerle K, Shayan P, Niemeyer CM, Flotho C |title=Expression analysis of alpha-NAC and ANX2 in juvenile myelomonocytic leukemia using SMART polymerase chain reaction and "virtual Northern" hybridization. |journal=Cancer Genet. Cytogenet. |volume=142 |issue= 2 |pages= 149–52 |year= 2003 |pmid= 12699894 |doi=10.1016/S0165-4608(02)00841-5 }}
• {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
• {{cite journal | vauthors=Al-Shanti N, Steward CG, Garland RJ, Rowbottom AW |title=Investigation of alpha nascent polypeptide-associated complex functions in a human CD8(+) T cell ex vivo expansion model using antisense oligonucleotides. |journal=Immunology |volume=112 |issue= 3 |pages= 397–403 |year= 2004 |pmid= 15196207 |doi= 10.1111/j.1365-2567.2004.01893.x | pmc=1782496 }}
• {{cite journal |vauthors=Ballif BA, Villén J, Beausoleil SA, etal |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell. Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 }}

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