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词条 Neuregulin 4
释义

  1. Function

  2. Clinical significance

  3. References

  4. Further reading

{{Infobox_gene}}Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene.[1][2][3]

Function

The neuregulins, including NRG4, activate erb-b2 receptor tyrosine kinase 4 (ERBB4) to initiating cell signaling through cytosolic tyrosine phosphorylation.[3]

Clinical significance

Loss of expression of NRG4 is frequently seen in advanced bladder cancer while increased NRG4 expression correlates to better survival.[4]

References

1. ^{{cite web | title = Entrez Gene: NRG4 neuregulin 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=145957 | accessdate = }}
2. ^{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal | title = Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 26 | pages = 16899–903 |date=December 2002 | pmid = 12477932 | pmc = 139241 | doi = 10.1073/pnas.242603899 | url = | issn = }}
3. ^1 {{cite journal |vauthors=Harari D, Tzahar E, Romano J, Shelly M, Pierce JH, Andrews GC, Yarden Y | title = Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase | journal = Oncogene | volume = 18 | issue = 17 | pages = 2681–9 |date=April 1999 | pmid = 10348342 | doi = 10.1038/sj.onc.1202631 | url = | issn = }}
4. ^{{cite journal |vauthors=Memon AA, Sorensen BS, Melgard P, Fokdal L, Thykjaer T, Nexo E | title = Expression of HER3, HER4 and their ligand heregulin-4 is associated with better survival in bladder cancer patients | journal = Br. J. Cancer | volume = 91 | issue = 12 | pages = 2034–41 |date=December 2004 | pmid = 15583696 | doi = 10.1038/sj.bjc.6602251 | url = | issn = | pmc = 2409781 }}

Further reading

{{refbegin | 2}}
  • {{cite journal |vauthors=Révillion F, Lhotellier V, Hornez L, Bonneterre J, Peyrat JP | title = ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis | journal = Ann. Oncol. | volume = 19 | issue = 1 | pages = 73–80 |date=January 2008 | pmid = 17962208 | doi = 10.1093/annonc/mdm431 | url = | issn = }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928 }}
  • {{cite journal |vauthors=Hayes NV, Newsam RJ, Baines AJ, Gullick WJ |title=Characterization of the cell membrane-associated products of the Neuregulin 4 gene. |journal=Oncogene |volume=27 |issue= 5 |pages= 715–20 |year= 2008 |pmid= 17684490 |doi= 10.1038/sj.onc.1210689 }}
  • {{cite journal |vauthors=Hayes NV, Blackburn E, Smart LV, etal |title=Identification and characterization of novel spliced variants of neuregulin 4 in prostate cancer. |journal=Clin. Cancer Res. |volume=13 |issue= 11 |pages= 3147–55 |year= 2007 |pmid= 17545517 |doi= 10.1158/1078-0432.CCR-06-2237 }}
{{refend}}{{Nerve growth factor family}}{{Growth factor receptor modulators}}{{gene-15-stub}}

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