| 词条 | NNC 38-1049 |
| 释义 |
| verifiedrevid = 415856907 | ImageFile = NNC 38-1049.svg | ImageSize = 230 | IUPACName = 1-(4-chlorophenyl)-4-(4-cyclopentylpiperazine-1-yl)-4-oxobutan-1-one | OtherNames = | Section1 = {{Chembox Identifiers | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 7974195 | InChI = 1/C19H25ClN2O2/c20-16-7-5-15(6-8-16)18(23)9-10-19(24)22-13-11-21(12-14-22)17-3-1-2-4-17/h5-8,17H,1-4,9-14H2 | InChIKey = VPARRMQGLNFBBR-UHFFFAOYAT | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 97170 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C19H25ClN2O2/c20-16-7-5-15(6-8-16)18(23)9-10-19(24)22-13-11-21(12-14-22)17-3-1-2-4-17/h5-8,17H,1-4,9-14H2 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = VPARRMQGLNFBBR-UHFFFAOYSA-N | CASNo_Ref = {{cascite|correct|??}} | CASNo=757183-18-9 | PubChem = 9798429 | SMILES = Clc1ccc(cc1)C(=O)CCC(=O)N3CCN(C2CCCC2)CC3 }} | Section2 = {{Chembox Properties | Formula=C19H25ClN2O2 | MolarMass = 348.866 g/mol | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = | Section3 = {{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}NNC 38-1049 is a histamine antagonist selective for the H3 subtype. It has anorectic effects in animal studies and is being researched as a potential treatment for obesity.[1][2] References1. ^{{cite journal |vauthors=Malmlöf K, Zaragoza F, Golozoubova V, etal |title=Influence of a selective histamine H3 receptor antagonist on hypothalamic neural activity, food intake and body weight |journal=Int J Obes (Lond) |volume=29 |issue=12 |pages=1402–12 |date=December 2005 |pmid=16151415 |doi=10.1038/sj.ijo.0803036}} {{Histaminergics}}{{gastrointestinal-drug-stub}}{{ketone-stub}}2. ^Malmlöf K, Golozoubova V, Peschke B, Wulff BS, Refsgaard HH, Johansen PB, Cremers T, Rimvall K. Increase of neuronal histamine in obese rats is associated with decreases in body weight and plasma triglycerides. Obesity (Silver Spring). 2006 Dec;14(12):2154-62. {{PMID|17189541}} 6 : Carboxamides|Aromatic ketones|Chloroarenes|H3 receptor antagonists|Piperazines|Cyclopentanes |
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