| 词条 | Pipermethystine |
| 释义 |
| ImageFile = Pipermethystine.png | ImageSize = 300px | ImageAlt = | IUPACName = | OtherNames = |Section1={{Chembox Identifiers | CASNo = | PubChem = 11231515 | ChemSpiderID = 9406563 | SMILES = O=C(N1C(=O)\\C=C/[C@H](OC(=O)C)C1)CCc2ccccc2 | InChI = 1/C16H17NO4/c1-12(18)21-14-8-10-16(20)17(11-14)15(19)9-7-13-5-3-2-4-6-13/h2-6,8,10,14H,7,9,11H2,1H3/t14-/m0/s1 | InChIKey = JLNNQCUATONMIT-AWEZNQCLBW | StdInChI = 1S/C16H17NO4/c1-12(18)21-14-8-10-16(20)17(11-14)15(19)9-7-13-5-3-2-4-6-13/h2-6,8,10,14H,7,9,11H2,1H3/t14-/m0/s1 | StdInChIKey = JLNNQCUATONMIT-AWEZNQCLSA-N |Section2={{Chembox Properties | Formula = C16H17NO4 | MolarMass = 287.31 g/mol | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} Pipermethystine is a toxic alkaloid present in the aerial (aboveground) portions of the kava plant. It is not a kavalactone, containing no lactone structure. Correctly prepared kava root products will contain almost no pipermethystine.{{citation needed|date=January 2016}} ToxicitySeveral studies suggest pipermethystine induces hepatotoxicity in humans, and was first believed to be the cause of liver failure in individuals consuming kava supplements, but not in proper root powder or fresh root, which is consumed in the traditional kava cultures of Polynesia.[1] Later analyses of the implicated drug materials and products revealed that medical Kava extracts contain less than 45 ppm of this alkaloid, while the leaves contain about 0.2% (2000ppm). Based on this retrospective study, pipermethystine is an unlikely cause for the observed hepatotoxicity of commercial Kava preparations.[2] References1. ^{{cite journal | author=Nerurkar, PV| title=In vitro toxicity of kava alkaloid, pipermethystine, in HepG2 cells compared to kavalactones | journal=Toxicological Sciences | volume=79 | issue=1 | year=2004 | pages=106–111 | pmid=14737001 | doi=10.1093/toxsci/kfh067|display-authors=etal}} {{alkaloids}}{{pharma-stub}}2. ^{{cite journal |vauthors=Lechtenberg M, Quandt B, Schmidt M, Nahrstedt A |title=Is the alkaloid pipermethystine connected with the claimed liver toxicity of Kava products? |journal=Pharmazie |volume=63 |issue=1 |pages=71–4 |year=2008 |pmid=18271308 |doi= |url=}} 1 : Kava |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。