“PLCG2”的意思、由来-开放百科全书

Function

Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide-specific phospholipase C enzymes, C-beta is regulated by heterotrimeric G protein-coupled receptors, while the closely related C-gamma-1 (PLCG1; MIM 172420) and C-gamma-2 enzymes are controlled by receptor tyrosine kinases. The C-gamma-1 and C-gamma-2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3.[supplied by OMIM]^[2]

References

1. ^{{cite journal | vauthors = Hernandez D, Egan SE, Yulug IG, Fisher EM | title = Mapping the gene that encodes phosphatidylinositol-specific phospholipase C-gamma 2 in the human and the mouse | journal = Genomics | volume = 23 | issue = 2 | pages = 504–7 | date = February 1995 | pmid = 7835906 | pmc = | doi = 10.1006/geno.1994.1533 }}
2. ^¹{{cite web | title = Entrez Gene: PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5336| accessdate = }}
3. ^{{cite journal | vauthors = Yasuda T, Tezuka T, Maeda A, Inazu T, Yamanashi Y, Gu H, Kurosaki T, Yamamoto T | title = Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells | journal = J. Exp. Med. | volume = 196 | issue = 1 | pages = 51–63 | date = July 2002 | pmid = 12093870 | pmc = 2194016 | doi = 10.1084/jem.20020068}}
4. ^¹{{cite journal | vauthors = Guo B, Kato RM, Garcia-Lloret M, Wahl MI, Rawlings DJ | title = Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex | journal = Immunity | volume = 13 | issue = 2 | pages = 243–53 | date = August 2000 | pmid = 10981967 | doi = 10.1016/s1074-7613(00)00024-8}}
5. ^{{cite journal | vauthors = Pleiman CM, Clark MR, Gauen LK, Winitz S, Coggeshall KM, Johnson GL, Shaw AS, Cambier JC | title = Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase | journal = Mol. Cell. Biol. | volume = 13 | issue = 9 | pages = 5877–87 | date = September 1993 | pmid = 8395016 | pmc = 360336 | doi = 10.1128/MCB.13.9.5877}}
6. ^¹²{{cite journal | vauthors = Boudot C, Kadri Z, Petitfrère E, Lambert E, Chrétien S, Mayeux P, Haye B, Billat C | title = Phosphatidylinositol 3-kinase regulates glycosylphosphatidylinositol hydrolysis through PLC-gamma(2) activation in erythropoietin-stimulated cells | journal = Cell. Signal. | volume = 14 | issue = 10 | pages = 869–78 | date = October 2002 | pmid = 12135708 | doi = 10.1016/s0898-6568(02)00036-0}}
7. ^{{cite journal | vauthors = Perskvist N, Zheng L, Stendahl O | title = Activation of human neutrophils by Mycobacterium tuberculosis H37Ra involves phospholipase C gamma 2, Shc adapter protein, and p38 mitogen-activated protein kinase | journal = J. Immunol. | volume = 164 | issue = 2 | pages = 959–65 | date = January 2000 | pmid = 10623845 | doi = 10.4049/jimmunol.164.2.959}}

Further reading

{{cite journal | vauthors = Fruman DA, Satterthwaite AB, Witte ON | title = Xid-like phenotypes: a B cell signalosome takes shape | journal = Immunity | volume = 13 | issue = 1 | pages = 1–3 | year = 2000 | pmid = 10933389 | doi = 10.1016/S1074-7613(00)00002-9 }}

{{cite journal | vauthors = Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G | title = Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway | journal = J. Clin. Invest. | volume = 86 | issue = 6 | pages = 2117–24 | year = 1990 | pmid = 1979339 | pmc = 329852 | doi = 10.1172/JCI114950 }}

{{cite journal | vauthors = Ohta S, Matsui A, Nazawa Y, Kagawa Y | title = Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes | journal = FEBS Lett. | volume = 242 | issue = 1 | pages = 31–5 | year = 1988 | pmid = 2849563 | doi = 10.1016/0014-5793(88)80979-7 }}

{{cite journal | vauthors = Yan W, Ratnam M | title = Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal | journal = Biochemistry | volume = 34 | issue = 44 | pages = 14594–600 | year = 1995 | pmid = 7578066 | doi = 10.1021/bi00044a039 }}

{{cite journal | vauthors = Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D, Bertolaso L, Bosco D, Robuffo I, Capitani S | title = Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line | journal = Eur. J. Immunol. | volume = 25 | issue = 9 | pages = 2695–700 | year = 1995 | pmid = 7589147 | doi = 10.1002/eji.1830250944 }}

{{cite journal | vauthors = Liao F, Shin HS, Rhee SG | title = In vitro tyrosine phosphorylation of PLC-gamma 1 and PLC-gamma 2 by src-family protein tyrosine kinases | journal = Biochem. Biophys. Res. Commun. | volume = 191 | issue = 3 | pages = 1028–33 | year = 1993 | pmid = 7682059 | doi = 10.1006/bbrc.1993.1320 }}

{{cite journal | vauthors = Daniel JL, Dangelmaier C, Smith JB | title = Evidence for a role for tyrosine phosphorylation of phospholipase C gamma 2 in collagen-induced platelet cytosolic calcium mobilization | journal = Biochem. J. | volume = 302 | issue = 2 | pages = 617–22 | year = 1994 | pmid = 8093016 | pmc = 1137272 | doi = 10.1042/bj3020617}}

{{cite journal | vauthors = Obermeier A, Lammers R, Wiesmüller KH, Jung G, Schlessinger J, Ullrich A | title = Identification of Trk binding sites for SHC and phosphatidylinositol 3'-kinase and formation of a multimeric signaling complex | journal = J. Biol. Chem. | volume = 268 | issue = 31 | pages = 22963–6 | year = 1993 | pmid = 8226808 | doi = }}

{{cite journal | vauthors = Pleiman CM, Clark MR, Gauen LK, Winitz S, Coggeshall KM, Johnson GL, Shaw AS, Cambier JC | title = Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase | journal = Mol. Cell. Biol. | volume = 13 | issue = 9 | pages = 5877–87 | year = 1993 | pmid = 8395016 | pmc = 360336 | doi = 10.1128/MCB.13.9.5877}}

{{cite journal | vauthors = Sidorenko SP, Law CL, Klaus SJ, Chandran KA, Takata M, Kurosaki T, Clark EA | title = Protein kinase C mu (PKC mu) associates with the B cell antigen receptor complex and regulates lymphocyte signaling | journal = Immunity | volume = 5 | issue = 4 | pages = 353–63 | year = 1996 | pmid = 8885868 | doi = 10.1016/S1074-7613(00)80261-7 }}

{{cite journal | vauthors = Kang JS, Kohlhuber F, Hug H, Marmé D, Eick D, Ueffing M | title = Cloning and functional analysis of the hematopoietic cell-specific phospholipase C(gamma)2 promoter | journal = FEBS Lett. | volume = 399 | issue = 1–2 | pages = 14–20 | year = 1996 | pmid = 8980110 | doi = 10.1016/S0014-5793(96)01276-8 }}

{{cite journal | vauthors = Chen P, Mayne M, Power C, Nath A | title = The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases | journal = J. Biol. Chem. | volume = 272 | issue = 36 | pages = 22385–8 | year = 1997 | pmid = 9278385 | doi = 10.1074/jbc.272.36.22385 }}

{{cite journal | vauthors = Cunningham SA, Arrate MP, Brock TA, Waxham MN | title = Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites | journal = Biochem. Biophys. Res. Commun. | volume = 240 | issue = 3 | pages = 635–9 | year = 1997 | pmid = 9398617 | doi = 10.1006/bbrc.1997.7719 }}

{{cite journal | vauthors = Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C | title = HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease | journal = Neuroimmunomodulation | volume = 5 | issue = 3–4 | pages = 184–92 | year = 1998 | pmid = 9730685 | doi = 10.1159/000026336 }}

{{cite journal | vauthors = Bai RY, Dieter P, Peschel C, Morris SW, Duyster J | title = Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity | journal = Mol. Cell. Biol. | volume = 18 | issue = 12 | pages = 6951–61 | year = 1998 | pmid = 9819383 | pmc = 109278 | doi = 10.1128/mcb.18.12.6951}}

{{cite journal | vauthors = Tomassetti A, Bottero F, Mazzi M, Miotti S, Colnaghi MI, Canevari S | title = Molecular requirements for attachment of the glycosylphosphatidylinositol anchor to the human alpha folate receptor | journal = J. Cell. Biochem. | volume = 72 | issue = 1 | pages = 111–8 | year = 1999 | pmid = 10025672 | doi = 10.1002/(SICI)1097-4644(19990101)72:1<111::AID-JCB12>3.0.CO;2-1 }}

{{cite journal | vauthors = Shen Z, Batzer A, Koehler JA, Polakis P, Schlessinger J, Lydon NB, Moran MF | title = Evidence for SH3 domain directed binding and phosphorylation of Sam68 by Src | journal = Oncogene | volume = 18 | issue = 33 | pages = 4647–53 | year = 1999 | pmid = 10467411 | doi = 10.1038/sj.onc.1203079 }}

{{cite journal | vauthors = Gross BS, Melford SK, Watson SP | title = Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets | journal = Eur. J. Biochem. | volume = 263 | issue = 3 | pages = 612–23 | year = 1999 | pmid = 10469124 | doi = 10.1046/j.1432-1327.1999.00560.x }}

{{cite journal | vauthors = Haughey NJ, Holden CP, Nath A, Geiger JD | title = Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat | journal = J. Neurochem. | volume = 73 | issue = 4 | pages = 1363–74 | year = 1999 | pmid = 10501179 | doi = 10.1046/j.1471-4159.1999.0731363.x }}

1 : EC 3.1.4