请输入您要查询的百科知识：

　

词条 PTPN7
释义

  1. Function

  2. Interactions

  3. References

  4. Further reading

{{Infobox_gene}}Protein tyrosine phosphatase non-receptor type 7 is an enzyme that in humans is encoded by the PTPN7 gene.[1][2]

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.[2]

Interactions

PTPN7 has been shown to interact with MAPK3[3][4][5] and MAPK1.[3][5]

References

1. ^{{cite journal | vauthors = Adachi M, Sekiya M, Isobe M, Kumura Y, Ogita Z, Hinoda Y, Imai K, Yachi A | title = Molecular cloning and chromosomal mapping of a human protein-tyrosine phosphatase LC-PTP | journal = Biochem Biophys Res Commun | volume = 186 | issue = 3 | pages = 1607–15 | date = September 1992 | pmid = 1510684 | pmc = | doi = 10.1016/S0006-291X(05)81592-X }}
2. ^1 {{cite web | title = Entrez Gene: PTPN7 protein tyrosine phosphatase, non-receptor type 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5778| accessdate = }}
3. ^1 {{cite journal | vauthors = Pettiford SM, Herbst R | title = The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP | journal = Oncogene | volume = 19 | issue = 7 | pages = 858–69 | date = February 2000 | pmid = 10702794 | doi = 10.1038/sj.onc.1203408 }}
4. ^{{cite journal | vauthors = Saxena M, Williams S, Taskén K, Mustelin T | title = Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase | journal = Nat. Cell Biol. | volume = 1 | issue = 5 | pages = 305–11 | date = September 1999 | pmid = 10559944 | doi = 10.1038/13024 }}
5. ^1 {{cite journal | vauthors = Saxena M, Williams S, Brockdorff J, Gilman J, Mustelin T | title = Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP) | journal = J. Biol. Chem. | volume = 274 | issue = 17 | pages = 11693–700 | date = April 1999 | pmid = 10206983 | doi = 10.1074/jbc.274.17.11693 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Adachi M, Sekiya M, Arimura Y, Takekawa M, Itoh F, Hinoda Y, Imai K, Yachi A | title = Protein-tyrosine phosphatase expression in pre-B cell NALM-6 | journal = Cancer Res. | volume = 52 | issue = 3 | pages = 737–40 | year = 1992 | pmid = 1370651 | doi = }}
  • {{cite journal | vauthors = Zanke B, Suzuki H, Kishihara K, Mizzen L, Minden M, Pawson A, Mak TW | title = Cloning and expression of an inducible lymphoid-specific, protein tyrosine phosphatase (HePTPase) | journal = Eur. J. Immunol. | volume = 22 | issue = 1 | pages = 235–9 | year = 1992 | pmid = 1530918 | doi = 10.1002/eji.1830220134 }}
  • {{cite journal | vauthors = Swieter M, Berenstein EH, Swaim WD, Siraganian RP | title = Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells induces tyrosine phosphorylation of the cytosolic protein-tyrosine phosphatase HePTP | journal = J. Biol. Chem. | volume = 270 | issue = 37 | pages = 21902–6 | year = 1995 | pmid = 7545170 | doi = 10.1074/jbc.270.37.21902 }}
  • {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
  • {{cite journal | vauthors = Zanke B, Squire J, Griesser H, Henry M, Suzuki H, Patterson B, Minden M, Mak TW | title = A hematopoietic protein tyrosine phosphatase (HePTP) gene that is amplified and overexpressed in myeloid malignancies maps to chromosome 1q32.1 | journal = Leukemia | volume = 8 | issue = 2 | pages = 236–44 | year = 1994 | pmid = 8309248 | doi = }}
  • {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
  • {{cite journal | vauthors = Saxena M, Williams S, Gilman J, Mustelin T | title = Negative regulation of T cell antigen receptor signal transduction by hematopoietic tyrosine phosphatase (HePTP) | journal = J. Biol. Chem. | volume = 273 | issue = 25 | pages = 15340–4 | year = 1998 | pmid = 9624114 | doi = 10.1074/jbc.273.25.15340 }}
  • {{cite journal | vauthors = Saxena M, Williams S, Brockdorff J, Gilman J, Mustelin T | title = Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP) | journal = J. Biol. Chem. | volume = 274 | issue = 17 | pages = 11693–700 | year = 1999 | pmid = 10206983 | doi = 10.1074/jbc.274.17.11693 }}
  • {{cite journal | vauthors = Oh-hora M, Ogata M, Mori Y, Adachi M, Imai K, Kosugi A, Hamaoka T | title = Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase | journal = J. Immunol. | volume = 163 | issue = 3 | pages = 1282–8 | year = 1999 | pmid = 10415025 | doi = }}
  • {{cite journal | vauthors = Saxena M, Williams S, Taskén K, Mustelin T | title = Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase | journal = Nat. Cell Biol. | volume = 1 | issue = 5 | pages = 305–11 | year = 1999 | pmid = 10559944 | doi = 10.1038/13024 }}
  • {{cite journal | vauthors = Pettiford SM, Herbst R | title = The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP | journal = Oncogene | volume = 19 | issue = 7 | pages = 858–69 | year = 2000 | pmid = 10702794 | doi = 10.1038/sj.onc.1203408 }}
  • {{cite journal | vauthors = Gjörloff-Wingren A, Saxena M, Han S, Wang X, Alonso A, Renedo M, Oh P, Williams S, Schnitzer J, Mustelin T | title = Subcellular localization of intracellular protein tyrosine phosphatases in T cells | journal = Eur. J. Immunol. | volume = 30 | issue = 8 | pages = 2412–21 | year = 2000 | pmid = 10940933 | doi = 10.1002/1521-4141(2000)30:8<2412::AID-IMMU2412>3.0.CO;2-J }}
  • {{cite journal | vauthors = Tartaglia M, Mehler EL, Goldberg R, Zampino G, Brunner HG, Kremer H, van der Burgt I, Crosby AH, Ion A, Jeffery S, Kalidas K, Patton MA, Kucherlapati RS, Gelb BD | title = Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome | journal = Nat. Genet. | volume = 29 | issue = 4 | pages = 465–8 | year = 2001 | pmid = 11704759 | doi = 10.1038/ng772 }}
  • {{cite journal | vauthors = Wang ZX, Zhou B, Wang QM, Zhang ZY | title = A kinetic approach for the study of protein phosphatase-catalyzed regulation of protein kinase activity | journal = Biochemistry | volume = 41 | issue = 24 | pages = 7849–57 | year = 2002 | pmid = 12056917 | doi = 10.1021/bi025776m }}
  • {{cite journal | vauthors = Digilio MC, Conti E, Sarkozy A, Mingarelli R, Dottorini T, Marino B, Pizzuti A, Dallapiccola B | title = Grouping of Multiple-Lentigines/LEOPARD and Noonan Syndromes on the PTPN11 Gene | journal = Am. J. Hum. Genet. | volume = 71 | issue = 2 | pages = 389–94 | year = 2002 | pmid = 12058348 | pmc = 379170 | doi = 10.1086/341528 }}
  • {{cite journal | vauthors = Kosaki K, Suzuki T, Muroya K, Hasegawa T, Sato S, Matsuo N, Kosaki R, Nagai T, Hasegawa Y, Ogata T | title = PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) mutations in seven Japanese patients with Noonan syndrome | journal = J. Clin. Endocrinol. Metab. | volume = 87 | issue = 8 | pages = 3529–33 | year = 2002 | pmid = 12161469 | doi = 10.1210/jc.87.8.3529 }}
  • {{cite journal | vauthors = Pettiford SM, Herbst R | title = The protein tyrosine phosphatase HePTP regulates nuclear translocation of ERK2 and can modulate megakaryocytic differentiation of K562 cells | journal = Leukemia | volume = 17 | issue = 2 | pages = 366–78 | year = 2003 | pmid = 12592337 | doi = 10.1038/sj.leu.2402767 }}
{{refend}}{{PDB Gallery|geneid=5778}}{{Protein tyrosine phosphatases}}{{gene-1-stub}}
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/9/22 22:29:42