1. Biography

2. Research

3. Clinical Practice

4. Publications

5. Awards and honors

6. Selected publications

7. References

8. External links

Professor Ralph Weissleder is an American clinician scientist.

Biography

Ralph Weissleder (born November 8, 1958 in Zell am Harmersbach, Germany) is a Professor at Harvard Medical School, Director of the Center for Systems Biology at Massachusetts General Hospital (MGH) and an Attending Interventional Radiologist at MGH.

Ralph Weissleder graduated from University of Heidelberg in 1985. Following his degrees, Dr. Weissleder completed an Internship and Residency at University Hospital, Monterrey, Mexico. In 1986, Dr. Weissleder moved to Boston (USA) where he pursued post-doctoral research (1986-1989) and then clinical training in radiology at Massachusetts General Hospital (MGH) and at Harvard Medical School (HMS). In 1994, Dr. Weissleder became Assistant Professor at HMS, Full Professor in 2001 (Department of Radiology), and remains an active physician at Massachusetts General Hospital. In 2007, Dr. Weissleder was appointed Director of the MGH Center for Systems Biology and in 2008, he was also appointed Professor in Systems Biology at HMS. Dr. Weissleder is a member of the Dana-Farber/Harvard Cancer Center.

Dr. Weissleder has received honorary degrees from The Universidad Autonoma de Nuevo León, Mexico (2007) and from Harvard University (2001).

Research

Dr. Weissleder is a widely recognized and cited researcher in biotechnology, especially in the fields of imaging and next-gen diagnostics. His research interests include the development of novel molecular imaging techniques, tools for early disease detection as well as the development of nanomaterials for sensing and systems analysis. His research is translational in nature and several of his developments have led to commercialized technologies and advanced clinical trials. He is cofounder of T2 Biosystems, Lumicell, [https://innovationlabs.harvard.edu/current-team/accure-health/ Accure Health], VisEn Medical (acquired by Perkin Elmer), and an advisor to several other biotech companies (Moderna, Alivio Therapeutics, Tarveda Therapeutics, BioAnalytix).

Clinical Practice

Dr. Weissleder’s practices at Massachusetts General Hospital which is widely recognized ^[1] for its patient care and ranks among the most accomplished and innovative medical institutions in the world. He is a faculty member of the Department of Radiology where his clinical specialty is in interventional radiology. He is a member of the Massachusetts General Physicians Organization. He has trained over 200 fellows.

Publications

Dr. Weissleder has published over [https://csb.mgh.harvard.edu/weissleder/publications?all=true 900 publications] in peer reviewed journals, has authored and co-authored several textbooks and holds [https://patents.google.com/?inventor=Ralph+Weissleder 68 patents]. His work has been cited over 132,000 times and he has an h-index of 179.

Awards and honors

He is an elected member of the US National Academy of Medicine, the American Academy of Arts and Sciences and the German National Academy of Sciences (Leopoldina)

His work has also been honored with numerous awards including the Millennium Pharmaceuticals Innovator Award (2003), the J. Taylor International Prize in Medicine (2004), the AUR Memorial Award,^[2] the ARRS President's Award,^[3] The Society for Molecular Imaging Lifetime Achievement Award, the Academy of Molecular Imaging 2006 Distinguished Basic Scientist Award,^[4] the 2008 RSNA Outstanding Researcher Award^[5] and the 2011 European Society of Radiology Gold Medal.^[6]

Selected publications

• {{cite journal |vauthors= Pittet MJ, Garris CS, Arlauckas SP, Weissleder R |title= Recording the wild lives of immune cells. |journal=Science Immunology |volume=3 |issue=27 |pages=eaaq0491 |year =2018 |pmid=30194240 |doi= 10.1126/sciimmunol.aaq0491 |url=}}
• {{cite journal |vauthors=Rodell CB, Arlauckas SP, Cuccarese MF, Garris CS, Li R, Ahmed MS, Kohler RH, Pittet MJ, Weissleder R |title= TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy |journal= Nature Biomedical Engineering |volume= |issue= |pages= |year=2018 |pmid= | doi= 10.1038/s41551-018-0236-8}}
• {{cite journal |vauthors=Weissleder R, Schwaiger MC, Gambhir SS, Hricak H |title= Imaging approaches to optimize molecular therapies |journal= Sci Transl Med |volume= 8 |issue= 355 |pages= 355ps16 |year=2016 |pmid= 27605550 | doi= 10.1126/scitranslmed.aaf3936}}
• {{cite journal |vauthors=Pucci F, Garris C, Lai CP, Newton A, Pfirschke C, Engblom C, Alvarez D, Sprachman M, Evavold C, Magnuson A, von Andrian UH, Glatz K, Breakefield XO, Mempel TR, Weissleder R, Pittet MJ |title= SCS macrophages suppress melanoma by restricting tumor-derived vesicle–B cell interactions |journal= Science |volume= 352 |issue= 6282 |pages= 242–246 |year=2016 |pmid= 26989197 | doi= 10.1126/science.aaf1328|pmc= 4960636 }}
• {{cite journal |vauthors=Miller MA, Gadde S, Pfirschke C, Engblom C, Sprachman MM, Kohler RH, Yang KS, Laughney AM, Wojtkiewicz G, Kamal N, Bhonagiri S, Pittet MJ, Farokhzad OC, Weissleder R |title= Predicting therapeutic nano-medicine efficacy using a companion MR imaging nanoparticle |journal= Sci Transl Med |volume=7 |issue=314 |pages= 314ra183 |year=2015 |pmid= 26582898 | doi= 10.1126/scitranslmed.aac6522}}
• {{cite journal |author= Im H, Shao H, Park YI, Peterson VM, Castro CM, Weissleder R, Lee H |title= Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor |journal= Nat Biotechnol |volume=32 |issue=5 |pages= 490–5 |year=2014 |pmid= 24752081 | doi=10.1038/nbt.2886 |pmc=4356947}}
• {{cite journal |vauthors=Weissleder R, Nahrendorf M, Pittet MJ |title= Imaging macrophages with nanoparticles |journal= Nat Mater |volume=13 |issue=2 |pages= 125–38 |year=2014 |pmid= 24452356 | doi= 10.1038/nmat3780}}
• {{cite journal |vauthors=Laughney AM, Kim E, Sprachman MM, Miller MA, Kohler RH, Yang KS, Orth JD, Mitchison TJ, Weissleder R |title= Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin |journal= Science Transl Med |volume=6 |issue=261 |pages= 261ra152 |year=2014 |pmid=25378644 |doi=10.1126/scitranslmed.3009318 |pmc=4330962}}
• {{cite journal |author= Ullal AV, Peterson V, Agasti SS, Tuang S, Juric D, Castro CM, Weissleder R |title= Cancer Cell Profiling by Barcoding Allows Multiplexed Protein Analysis in Fine-Needle Aspirates |journal= Science Transl Med |volume=6 |issue=219 |pages= 219ra9|year=2014 |pmid=24431113 |doi=10.1126/scitranslmed.3007361 |pmc=4063286}}
• {{cite journal |author=Haun JB, Castro CM, Wang R, Peterson VM, Marinelli BS, Lee H, Weissleder R. |title= MicroNMR Enables Rapid and Multiplexed Molecular Analysis of Scant Human Cancer Cells |journal= Science Transl Med |volume=3 |issue=71 |pages=71ra16 |year=2011 |pmid=21346169 |doi=10.1126/scitranslmed.3002048 |pmc=3086073}}
• {{cite journal |author=Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo JL, Kohler RH, Chudnovskiy A, Waterman P, Aikawa E, Mempel TR, Libby P, Weissleder R, Pittet MJ |title= Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites |journal= Science |volume=325 |issue=5940 |pages=612–6 |year=2009 |pmid=19644120 |url= |doi=10.1126/science.1175202 |pmc=2803111}}
• {{cite journal |vauthors=Weissleder R, Pittet MJ |title=Imaging in the era of molecular oncology |journal=Nature |volume=452 |issue=7187 |pages=580–9 |date=April 2008 |pmid=18385732 |doi=10.1038/nature06917 |url= |pmc=2708079}}
• {{cite journal |vauthors=Lee H, Sun E, Ham D, Weissleder R |title=Chip-NMR biosensor for detection and molecular analysis of cells |journal=Nat. Med. |volume=14 |issue=8 |pages=869–74 |date=August 2008 |pmid=18607350 |doi=10.1038/nm.1711 |url= |pmc=2729055}}
• {{cite journal |author=Weissleder R |title=Molecular imaging in cancer |journal=Science |volume=312 |issue=5777 |pages=1168–71 |date=May 2006 |pmid=16728630 |doi=10.1126/science.1125949 |url=}}
• {{cite journal |vauthors=Weissleder R, Kelly K, Sun EY, Shtatland T, Josephson L |title=Cell-specific targeting of nanoparticles by multivalent attachment of small molecules |journal=Nat. Biotechnol. |volume=23 |issue=11 |pages=1418–23 |date=November 2005 |pmid=16244656 |doi=10.1038/nbt1159 |url=}}
• {{cite journal |vauthors=Harisinghani MG, Barentsz J, Hahn PF, etal |title=Noninvasive detection of clinically occult lymph-node metastases in prostate cancer |journal=N. Engl. J. Med. |volume=348 |issue=25 |pages=2491–9 |date=June 2003 |pmid=12815134 |doi=10.1056/NEJMoa022749 |url=}}
• {{cite journal |vauthors=Perez JM, Josephson L, O'Loughlin T, Högemann D, Weissleder R |title=Magnetic relaxation switches capable of sensing molecular interactions |journal=Nat. Biotechnol. |volume=20 |issue=8 |pages=816–20 |date=August 2002 |pmid=12134166 |doi=10.1038/nbt720 |url=}}
• {{cite journal |vauthors=Bremer C, Tung CH, Weissleder R |title=In vivo molecular target assessment of matrix metalloproteinase inhibition |journal=Nat. Med. |volume=7 |issue=6 |pages=743–8 |date=June 2001 |pmid=11385514 |doi=10.1038/89126 |url=}}
• {{cite journal |vauthors=Lewin M, Carlesso N, Tung CH, etal |title=Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells |journal=Nat. Biotechnol. |volume=18 |issue=4 |pages=410–4 |date=April 2000 |pmid=10748521 |doi=10.1038/74464 |url=}}
• {{cite journal |vauthors=Weissleder R, Tung CH, Mahmood U, Bogdanov A |title=In vivo imaging of tumors with protease-activated near-infrared fluorescent probes |journal=Nat. Biotechnol. |volume=17 |issue=4 |pages=375–8 |date=April 1999 |pmid=10207887 |doi=10.1038/7933 |url=}}

References

External links

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