1. Function

2. References

3. Further reading

Function

This protein is a type I subclass member of the Regenerating protein family. The Reg protein family is a multi protein family grouped into four subclasses, types I, II, III and IV based on the primary structures of the proteins. This protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandomly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication.^[3]

References

Further reading

• {{cite journal | vauthors = De Reggi M, Gharib B | title = Protein-X, Pancreatic Stone-, Pancreatic thread-, reg-protein, P19, lithostathine, and now what? Characterization, structural analysis and putative function(s) of the major non-enzymatic protein of pancreatic secretions | journal = Curr. Protein Pept. Sci. | volume = 2 | issue =1 | pages = 19–42 | year = 2002 | pmid = 12369899 | doi = 10.2174/1389203013381233 }}
• {{cite journal | vauthors = Itoh T, Tsuzuki H, Katoh T, Teraoka H, Matsumoto K, Yoshida N, Terazono K, Watanabe T, Yonekura H, Yamamoto H | title = Isolation and characterization of human reg protein produced in Saccharomyces cerevisiae | journal = FEBS Lett. | volume = 272 | issue = 1–2 | pages = 85–8 | year = 1990 | pmid = 2226837 | doi = 10.1016/0014-5793(90)80454-Q }}
• {{cite journal | vauthors = de la Monte SM, Ozturk M, Wands JR | title = Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain | journal = J. Clin. Invest. | volume = 86 | issue = 3 | pages = 1004–13 | year = 1990 | pmid = 2394826 | pmc = 296822 | doi = 10.1172/JCI114762 }}
• {{cite journal | vauthors = De Caro AM, Adrich Z, Fournet B, Capon C, Bonicel JJ, De Caro JD, Rovery M | title = N-terminal sequence extension in the glycosylated forms of human pancreatic stone protein. The 5-oxoproline N-terminal chain is O-glycosylated on the 5th amino acid residue | journal = Biochim. Biophys. Acta | volume = 994 | issue = 3 | pages = 281–4 | year = 1989 | pmid = 2493268 | doi = 10.1016/0167-4838(89)90305-1 }}
• {{cite journal | vauthors = Giorgi D, Bernard JP, Rouquier S, Iovanna J, Sarles H, Dagorn JC | title = Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calcifying pancreatitis | journal = J. Clin. Invest. | volume = 84 | issue = 1 | pages = 100–6 | year = 1989 | pmid = 2525567 | pmc = 303958 | doi = 10.1172/JCI114128 }}
• {{cite journal | author = Stewart TA | title = The human reg gene encodes pancreatic stone protein | journal = Biochem. J. | volume = 260 | issue = 2 | pages = 622–3 | year = 1989 | pmid = 2764894 | pmc = 1138718 | doi = }}
• {{cite journal | vauthors = Terazono K, Yamamoto H, Takasawa S, Shiga K, Yonemura Y, Tochino Y, Okamoto H | title = A novel gene activated in regenerating islets | journal = J. Biol. Chem. | volume = 263 | issue = 5 | pages = 2111–4 | year = 1988 | pmid = 2963000 | doi = }}
• {{cite journal | vauthors = Rouimi P, Bonicel J, Rovery M, De Caro A | title = Cleavage of the Arg-Ile bond in the native polypeptide chain of human pancreatic stone protein | journal = FEBS Lett. | volume = 216 | issue = 2 | pages = 195–9 | year = 1987 | pmid = 3108036 | doi = 10.1016/0014-5793(87)80688-9 }}
• {{cite journal | vauthors = Rouimi P, de Caro J, Bonicel J, Rovery M, de Caro A | title = The disulfide bridges of the immunoreactive forms of human pancreatic stone protein isolated from pancreatic juice | journal = FEBS Lett. | volume = 229 | issue = 1 | pages = 171–4 | year = 1988 | pmid = 3345835 | doi = 10.1016/0014-5793(88)80820-2 }}
• {{cite journal | vauthors = Montalto G, Bonicel J, Multigner L, Rovery M, Sarles H, De Caro A | title = Partial amino acid sequence of human pancreatic stone protein, a novel pancreatic secretory protein | journal = Biochem. J. | volume = 238 | issue = 1 | pages = 227–32 | year = 1987 | pmid = 3541906 | pmc = 1147119 | doi = }}
• {{cite journal | vauthors = De Caro AM, Bonicel JJ, Rouimi P, De Caro JD, Sarles H, Rovery M | title = Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice | journal = Eur. J. Biochem. | volume = 168 | issue = 1 | pages = 201–7 | year = 1987 | pmid = 3665916 | doi = 10.1111/j.1432-1033.1987.tb13405.x }}
• {{cite journal | vauthors = Gross J, Carlson RI, Brauer AW, Margolies MN, Warshaw AL, Wands JR | title = Isolation, characterization, and distribution of an unusual pancreatic human secretory protein | journal = J. Clin. Invest. | volume = 76 | issue = 6 | pages = 2115–26 | year = 1986 | pmid = 3908481 | pmc = 424321 | doi = 10.1172/JCI112216 }}
• {{cite journal | vauthors = Perfetti R, Hawkins AL, Griffin CA, Egan JM, Zenilman ME, Shuldiner AR | title = Assignment of the human pancreatic regenerating (REG) gene to chromosome 2p12 | journal = Genomics | volume = 20 | issue = 2 | pages = 305–7 | year = 1994 | pmid = 8020983 | doi = 10.1006/geno.1994.1173 }}
• {{cite journal | vauthors = Otonkoski T, Mally MI, Hayek A | title = Opposite effects of beta-cell differentiation and growth on reg expression in human fetal pancreatic cells | journal = Diabetes | volume = 43 | issue = 9 | pages = 1164–6 | year = 1994 | pmid = 8070617 | doi = 10.2337/diabetes.43.9.1164 }}
• {{cite journal | vauthors = Moriizumi S, Watanabe T, Unno M, Nakagawara K, Suzuki Y, Miyashita H, Yonekura H, Okamoto H | title = Isolation, structural determination and expression of a novel reg gene, human regI beta | journal = Biochim. Biophys. Acta | volume = 1217 | issue = 2 | pages = 199–202 | year = 1994 | pmid = 8110835 | doi = 10.1016/0167-4781(94)90035-3 }}
• {{cite journal | vauthors = Bartoli C, Gharib B, Giorgi D, Sansonetti A, Dagorn JC, Bergé-Lefranc JL | title = A gene homologous to the reg gene is expressed in the human pancreas | journal = FEBS Lett. | volume = 327 | issue = 3 | pages = 289–93 | year = 1993 | pmid = 8348956 | doi = 10.1016/0014-5793(93)81006-L }}
• {{cite journal | vauthors = Bertrand JA, Pignol D, Bernard JP, Verdier JM, Dagorn JC, Fontecilla-Camps JC | title = Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation | journal = EMBO J. | volume = 15 | issue = 11 | pages = 2678–84 | year = 1996 | pmid = 8654365 | pmc = 450203 | doi = }}
• {{cite journal | vauthors = Patard L, Stoven V, Gharib B, Bontems F, Lallemand JY, De Reggi M | title = What function for human lithostathine?: structural investigations by three-dimensional structure modeling and high-resolution NMR spectroscopy | journal = Protein Eng. | volume = 9 | issue = 11 | pages = 949–57 | year = 1997 | pmid = 8961348 | doi = 10.1093/protein/9.11.949 }}

• Convention on Limitation of Liability for Maritime Claims
• Convention on Modern Liberty
• Convention on psychotropic substances
• Convention on Psychotropic Substances
• Convention on Psychotropic Substances 1971
• Convention on Road Traffic (disambiguation)
• Convention on Supplementary Compensation for Nuclear Damage
• Convention on the Banning of Chemical Weapons
• Convention on the Conservation of Antarctic Marine Living Resources
• Convention on the Continental Shelf
• Convention on the continental shelf
• Convention on the elimination of all forms of racial discrimination
• Convention on the Elimination of Racial Discrimination
• Convention on the future of europe
• Convention on the Grant of the European Patents
• Convention on the Grant of the European Patents of 5 October 1973
• Convention on the High Seas
• Convention on the high seas
• Convention on the nationality of married women
• Convention on the physical protection of nuclear material
• Convention on the Physical Protection of Nuclear Material
• Convention on the privileges and immunities of the united nations
• Convention on the recognition of decisions recording a sex change
• Convention on the recognition of decisions regarding a sex change
• Convention on the Rights of Persons with Disabilities