Ruano may refer to:

• Alexis Ruano Delgado (born 1985), Spanish professional footballer
• Alfredo Ruano (died 1987), football player from El Salvador
• Aytami Ruano (born 1977), Spanish judoka
• Carlos Ruano (born 1925), Cuban American Artist
• German Ruano (born 1971), Guatemalan football defender
• Gualberto Ruano, MD, PhD, pioneer in personalized medicine and inventor of molecular diagnostic systems for managing viral diseases
• Roque Ruaño (1877–1935), Spanish priest-civil engineer
• Teodora Ruano (born 1969), Spanish track and road racing cyclist
• Virginia Ruano Pascual (born 1973), female Spanish professional tennis player

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