| 词条 | Simmondsin |
| 释义 |
| Watchedfields = changed | verifiedrevid = 386068889 | IUPAC_name = (2Z)-2-[(2S,3R,4S,6R)-2-hydroxy-3,4-dimethoxy-6-[(2R,3R,4S,5S,6R)-3,4, | image = Simmondsin.svg | width = 300 | tradename = | legal_status = | routes_of_administration = | metabolism = | elimination_half-life = | excretion = | CAS_number = 51771-52-9 | ATC_prefix = none | PubChem = 6437384 | ChemSpiderID = 4941947 | C=16 | H=25 | N=1 | O=9 | molecular_weight = 375.371 g/mol | smiles = N#C\\C=C2/[C@H](O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)CO)C[C@H](OC)[C@H](OC)[C@H]2O | StdInChI = 1S/C16H25NO9/c1-23-9-5-8(7(3-4-17)11(19)15(9)24-2)25-16-14(22)13(21)12(20)10(6-18)26-16/h3,8-16,18-22H,5-6H2,1-2H3/b7-3+/t8-,9+,10-,11+,12-,13+,14-,15+,16-/m1/s1 | StdInChIKey = KURSRHBVYUACKS-XGYNEUJOSA-N }}Simmondsin is an extract of jojoba seeds (pronounced "ho-HO-bah") (Simmondsia chinensis), it was traditionally thought to be a toxic substance due to jojoba seed meal causing weight loss in animals, but in year 2000 been researched as a potential treatment for reducing appetite of obese individuals by helping to reduce craving for food.[1] Several mechanisms {{explain|date=February 2016}} of action are thought to be involved in the appetite suppressant effect.[2][3][4][5] References1. ^United States Department of Agriculture, Agricultural Research Service. Simmondsin From Jojoba - Checked for Appetite Suppression {{Antiobesity preparations}}{{gastrointestinal-drug-stub}}2. ^Cokelaere MM, Busselen P, Flo G, Daenens P, Decuypere E, Kühn E, Van Boven M. Devazepide reverses the anorexic effect of simmondsin in the rat. Journal of Endocrinology. 1995 Dec;147(3):473-7. {{PMID|8543917}} 3. ^Flo G, Vermaut S, Van Boven M, Daenens P, Buyse J, Decuypere E, Kühn E, Cokelaere M. Comparison of the effects of simmondsin and cholecystokinin on metabolism, brown adipose tissue and the pancreas in food-restricted rats. Hormone and Metabolic Research. 1998 Aug;30(8):504-8. {{PMID|9761380}} 4. ^Flo G, Van Boven M, Vermaut S, Daenens P, Decuypere E, Cokelaere M. The vagus nerve is involved in the anorexigenic effect of simmondsin in the rat. Appetite. 2000 Apr;34(2):147-51. {{PMID|10744903}} 5. ^Boozer CN, Herron AJ. Simmondsin for weight loss in rats. International Journal of Obesity (London). 2006 Jul;30(7):1143-8. {{PMID|16462820}} 2 : Anorectics|Cyanogenic glycosides |
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