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词条 SLC4A3
释义

  1. See also

  2. References

  3. Further reading

{{Infobox_gene}}Anion exchange protein 3 is a membrane transport protein that in humans is encoded by the SLC4A3 gene.[1][2] AE3 is functionally similar to the Band 3 Cl−/HCO3− exchange protein but it is expressed primarily in brain neurons and in the heart. Like AE2 its activity is sensitive to pH.[3][4] AE3 mutations have been linked to seizures.[5][6]

See also

  • Solute carrier family

References

1. ^{{cite journal | vauthors = Su YR, Klanke CA, Houseal TW, Linn SC, Burk SE, Varvil TS, Otterud BE, Shull GE, Leppert MF, Menon AG | title = Molecular cloning and physical and genetic mapping of the human anion exchanger isoform 3 (SLC2C) gene to chromosome 2q36 | journal = Genomics | volume = 22 | issue = 3 | pages = 605–9 |date=Jan 1995 | pmid = 8001971 | pmc = | doi = 10.1006/geno.1994.1433 }}
2. ^{{cite web | title = Entrez Gene: SLC4A3 solute carrier family 4, anion exchanger, member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6508| accessdate = }}
3. ^{{cite journal | vauthors = Casey JR, Sly WS, Shah GN, Alvarez BV | title = Bicarbonate homeostasis in excitable tissues: role of AE3 Cl-/HCO3- exchanger and carbonic anhydrase XIV interaction | journal = Am. J. Physiol., Cell Physiol. | volume = 297 | issue = 5 | pages = C1091–102 |date=November 2009 | pmid = 19692653 | pmc = 2777400 | doi = 10.1152/ajpcell.00177.2009 }}
4. ^{{cite journal | vauthors = Hayashi H, Suruga K, Yamashita Y | title = Regulation of intestinal Cl-/HCO3- exchanger SLC26A3 by intracellular pH | journal = Am. J. Physiol., Cell Physiol. | volume = 296 | issue = 6 | pages = C1279–90 |date=June 2009 | pmid = 19321737 | doi = 10.1152/ajpcell.00638.2008 }}
5. ^{{cite journal | vauthors = Hentschke M, Wiemann M, Hentschke S, Kurth I, Hermans-Borgmeyer I, Seidenbecher T, Jentsch TJ, Gal A, Hübner CA | title = Mice with a targeted disruption of the Cl-/HCO3- exchanger AE3 display a reduced seizure threshold | journal = Mol. Cell. Biol. | volume = 26 | issue = 1 | pages = 182–91 |date=January 2006 | pmid = 16354689 | pmc = 1317631 | doi = 10.1128/MCB.26.1.182-191.2006 }}
6. ^{{cite journal | vauthors = Vilas GL, Johnson DE, Freund P, Casey JR | title = Characterization of an epilepsy-associated variant of the human Cl-/HCO3(-) exchanger AE3 | journal = Am. J. Physiol., Cell Physiol. | volume = 297 | issue = 3 | pages = C526–36 |date=September 2009 | pmid = 19605733 | doi = 10.1152/ajpcell.00572.2008 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors=Alper SL, Chernova MN, Stewart AK |title=Regulation of Na+-independent Cl-/HCO3- exchangers by pH. |journal=JOP |volume=2 |issue= 4 Suppl |pages= 171–5 |year= 2002 |pmid= 11875255 |doi= }}
  • {{cite journal | vauthors=Alper SL, Darman RB, Chernova MN, Dahl NK |title=The AE gene family of Cl/HCO3- exchangers. | series=15 |journal=J. Nephrol. |volume=Suppl 5 |issue= |pages= S41–53 |year= 2002 |pmid= 12027221 |doi= }}
  • {{cite journal |vauthors=Kopito RR, Lee BS, Simmons DM, etal |title=Regulation of intracellular pH by a neuronal homolog of the erythrocyte anion exchanger. |journal=Cell |volume=59 |issue= 5 |pages= 927–37 |year= 1990 |pmid= 2686841 |doi=10.1016/0092-8674(89)90615-6 |title-link=intracellular pH }}
  • {{cite journal |vauthors=Yannoukakos D, Stuart-Tilley A, Fernandez HA, etal |title=Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart. |journal=Circ. Res. |volume=75 |issue= 4 |pages= 603–14 |year= 1994 |pmid= 7923606 |doi= 10.1161/01.res.75.4.603}}
  • {{cite journal | vauthors=Morgans CW, Kopito RR |title=Association of the brain anion exchanger, AE3, with the repeat domain of ankyrin. | series=105 |journal=J. Cell Sci. |volume=( Pt 4) |issue= |pages= 1137–42 |year= 1993 |pmid= 8227202 |doi= }}
  • {{cite journal |vauthors=Dudeja PK, Hafez N, Tyagi S, etal |title=Expression of the Na+/H+ and Cl-/HCO-3 exchanger isoforms in proximal and distal human airways. |journal=Am. J. Physiol. |volume=276 |issue= 6 Pt 1 |pages= L971–8 |year= 1999 |pmid= 10362722 |doi= 10.1152/ajplung.1999.276.6.L971}}
  • {{cite journal |vauthors=Einum DD, Zhang J, Arneson PJ, etal |title=Genomic structure of human anion exchanger 3 and its potential role in hereditary neurological disease. |journal=Neurogenetics |volume=1 |issue= 4 |pages= 289–92 |year= 2000 |pmid= 10732805 |doi=10.1007/s100480050043 }}
  • {{cite journal |vauthors=Soleimani M, Greeley T, Petrovic S, etal |title=Pendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortex. |journal=Am. J. Physiol. Renal Physiol. |volume=280 |issue= 2 |pages= F356–64 |year= 2001 |pmid= 11208611 |doi= 10.1152/ajprenal.2001.280.2.f356}}
  • {{cite journal |vauthors=Alrefai WA, Tyagi S, Nazir TM, etal |title=Human intestinal anion exchanger isoforms: expression, distribution, and membrane localization. |journal=Biochim. Biophys. Acta |volume=1511 |issue= 1 |pages= 17–27 |year= 2001 |pmid= 11248201 |doi=10.1016/S0005-2736(00)00366-7 }}
  • {{cite journal | vauthors=Sterling D, Reithmeier RA, Casey JR |title=A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers. |journal=J. Biol. Chem. |volume=276 |issue= 51 |pages= 47886–94 |year= 2002 |pmid= 11606574 |doi= 10.1074/jbc.M105959200 }}
  • {{cite journal | vauthors=Alvarez BV, Fujinaga J, Casey JR |title=Molecular basis for angiotensin II-induced increase of chloride/bicarbonate exchange in the myocardium. |journal=Circ. Res. |volume=89 |issue= 12 |pages= 1246–53 |year= 2002 |pmid= 11739292 |doi=10.1161/hh2401.101907 }}
  • {{cite journal | vauthors=Wang Z, Petrovic S, Mann E, Soleimani M |title=Identification of an apical Cl(-)/HCO3(-) exchanger in the small intestine. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=282 |issue= 3 |pages= G573–9 |year= 2002 |pmid= 11842009 |doi= 10.1152/ajpgi.00338.2001 }}
  • {{cite journal |vauthors=Al-Bazzaz FJ, Hafez N, Tyagi S, etal |title=Detection of Cl--HCO3- and Na+-H+ exchangers in human airways epithelium. |journal=JOP |volume=2 |issue= 4 Suppl |pages= 285–90 |year= 2002 |pmid= 11875273 |doi= }}
  • {{cite journal | vauthors=Sterling D, Alvarez BV, Casey JR |title=The extracellular component of a transport metabolon. Extracellular loop 4 of the human AE1 Cl-/HCO3- exchanger binds carbonic anhydrase IV. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25239–46 |year= 2002 |pmid= 11994299 |doi= 10.1074/jbc.M202562200 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
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