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词条 SOCS7
释义

  1. Model organisms

  2. Interactions

  3. References

  4. Further reading

{{Infobox_gene}}Suppressor of cytokine signaling 7 is a protein that in humans is encoded by the SOCS7 gene.[1][2][3]

Model organisms

Model organisms have been used in the study of SOCS7 function. A conditional knockout mouse line, called Socs7tm1a(EUCOMM)Wtsi[9][10] was generated as part of the International Knockout Mouse Consortium program—a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[11][12][13]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[7][14] Twenty five tests were carried out on mutant mice and one significant abnormality was observed: homozygous mutant males showed a decreased response to stress-induced hyperthermia.[7]

Interactions

SOCS7 has been shown to interact with NCK1.[1]

References

1. ^1 {{cite journal | vauthors = Matuoka K, Miki H, Takahashi K, Takenawa T | title = A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs | journal = Biochemical and Biophysical Research Communications | volume = 239 | issue = 2 | pages = 488–92 | date = Oct 1997 | pmid = 9344857 | pmc = | doi = 10.1006/bbrc.1997.7492 }}
2. ^{{cite journal | vauthors = Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ | title = The SOCS box: a tale of destruction and degradation | journal = Trends in Biochemical Sciences | volume = 27 | issue = 5 | pages = 235–41 | date = May 2002 | pmid = 12076535 | pmc = | doi = 10.1016/S0968-0004(02)02085-6 }}
3. ^{{cite web | title = Entrez Gene: SOCS7 suppressor of cytokine signaling 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30837| accessdate = }}
4. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBAJ/stress-induced-hyperthermia/ |title=Body temperature data for Socs7 |publisher=Wellcome Trust Sanger Institute}}
5. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBAJ/salmonella-challenge/ |title=Salmonella infection data for Socs7 |publisher=Wellcome Trust Sanger Institute}}
6. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBAJ/citrobacter-challenge/ |title=Citrobacter infection data for Socs7 |publisher=Wellcome Trust Sanger Institute}}
7. ^1 2 {{cite journal | doi = 10.1111/j.1755-3768.2010.4142.x | title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice | year = 2010 | author = Gerdin AK | journal = Acta Ophthalmologica | volume = 88 | pages = 925–7 }}
8. ^Mouse Resources Portal, Wellcome Trust Sanger Institute.
9. ^{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Socs7 |title=International Knockout Mouse Consortium}}
10. ^{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4432554 |title=Mouse Genome Informatics}}
11. ^{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–342 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}
12. ^{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}
13. ^{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}
14. ^{{cite journal | vauthors = van der Weyden L, White JK, Adams DJ, Logan DW | title = The mouse genetics toolkit: revealing function and mechanism | journal = Genome Biology | volume = 12 | issue = 6 | pages = 224 | year = 2011 | pmid = 21722353 | pmc = 3218837 | doi = 10.1186/gb-2011-12-6-224 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Cooney RN | title = Suppressors of cytokine signaling (SOCS): inhibitors of the JAK/STAT pathway | journal = Shock | volume = 17 | issue = 2 | pages = 83–90 | date = Feb 2002 | pmid = 11837794 | doi = 10.1097/00024382-200202000-00001 }}
  • {{cite journal | vauthors = Wormald S, Hilton DJ | title = Inhibitors of cytokine signal transduction | journal = The Journal of Biological Chemistry | volume = 279 | issue = 2 | pages = 821–4 | date = Jan 2004 | pmid = 14607831 | doi = 10.1074/jbc.R300030200 }}
  • {{cite journal | vauthors = Fujimoto M, Naka T | title = Regulation of cytokine signaling by SOCS family molecules | journal = Trends in Immunology | volume = 24 | issue = 12 | pages = 659–66 | date = Dec 2003 | pmid = 14644140 | doi = 10.1016/j.it.2003.10.008 }}
  • {{cite journal | vauthors = Hilton DJ, Richardson RT, Alexander WS, Viney EM, Willson TA, Sprigg NS, Starr R, Nicholson SE, Metcalf D, Nicola NA | title = Twenty proteins containing a C-terminal SOCS box form five structural classes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 1 | pages = 114–9 | date = Jan 1998 | pmid = 9419338 | pmc = 18144 | doi = 10.1073/pnas.95.1.114 }}
  • {{cite journal | vauthors = Dogusan Z, Hooghe-Peters EL, Berus D, Velkeniers B, Hooghe R | title = Expression of SOCS genes in normal and leukemic human leukocytes stimulated by prolactin, growth hormone and cytokines | journal = Journal of Neuroimmunology | volume = 109 | issue = 1 | pages = 34–9 | date = Sep 2000 | pmid = 10969179 | doi = 10.1016/S0165-5728(00)00300-3 }}
  • {{cite journal | vauthors = Krebs DL, Uren RT, Metcalf D, Rakar S, Zhang JG, Starr R, De Souza DP, Hanzinikolas K, Eyles J, Connolly LM, Simpson RJ, Nicola NA, Nicholson SE, Baca M, Hilton DJ, Alexander WS | title = SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation | journal = Molecular and Cellular Biology | volume = 22 | issue = 13 | pages = 4567–78 | date = Jul 2002 | pmid = 12052866 | pmc = 133908 | doi = 10.1128/MCB.22.13.4567-4578.2002 }}
  • {{cite journal | vauthors = Martens N, Wery M, Wang P, Braet F, Gertler A, Hooghe R, Vandenhaute J, Hooghe-Peters EL | title = The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin | journal = Experimental Cell Research | volume = 298 | issue = 1 | pages = 239–48 | date = Aug 2004 | pmid = 15242778 | doi = 10.1016/j.yexcr.2004.04.002 }}
  • {{cite journal | vauthors = Martens N, Uzan G, Wery M, Hooghe R, Hooghe-Peters EL, Gertler A | title = Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation | journal = The Journal of Biological Chemistry | volume = 280 | issue = 14 | pages = 13817–23 | date = Apr 2005 | pmid = 15677474 | doi = 10.1074/jbc.M411596200 }}
  • {{cite journal | vauthors = Banks AS, Li J, McKeag L, Hribal ML, Kashiwada M, Accili D, Rothman PB | title = Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans | journal = The Journal of Clinical Investigation | volume = 115 | issue = 9 | pages = 2462–71 | date = Sep 2005 | pmid = 16127460 | pmc = 1190369 | doi = 10.1172/JCI23853 }}
  • {{cite journal | vauthors = Kremer BE, Adang LA, Macara IG | title = Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7 | journal = Cell | volume = 130 | issue = 5 | pages = 837–50 | date = Sep 2007 | pmid = 17803907 | pmc = 2085444 | doi = 10.1016/j.cell.2007.06.053 }}
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1 : Genes mutated in mice
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