SPEB may refer to:

• Society for the Protection of the European Bison
• Agmatinase, an enzyme

• Thomas Philander Ryder
• Thomas Philip O'Neill
• Thomas-Philippe Pelletier
• Thomas Phillip O'Neill Jr
• Thomas Phillips (civil servant)
• Thomas Phillips (engineer)
• Thomas Phillips Mill Complex
• Thomas Phillips Price
• Thomas Phillip "Tip" O'Neill, Jr.
• Thomas Phoenix
• Thomas Pichlmann
• Thomas Pickard (disambiguation)
• Thomas Pickard (politician)
• Thomas Pickens Brady
• Thomas Pickering (disambiguation)
• Thomas Pierce
• Thomas Pierpoint
• Thomas Piketty
• Thomas Pilchard
• Thomas PIlgrim
• Thomas Pirker
• Thomas Pitfield
• Thomas Pitt (disambiguation)
• Thomas Pittman
• Thomas P. Ives House