“Spectrin repeat”的意思、由来-开放百科全书

词条

Spectrin repeat

释义

Human proteins containing this domain
References
Further reading

{{Pfam_box
| Symbol = Spectrin
| Name = Spectrin repeat
| image =PDB 1aj3 EBI.jpg
| width =
| caption = Structure of the spectrin repeat: a left-handed antiparallel triple-helical coiled-coil.^[1]
| Pfam= PF00435
| InterPro= IPR002017
| SMART=
| PROSITE = PDOC50083
| SCOP = 1aj3
| TCDB =
| CDD = cd00176
| OPM family=
| OPM protein=
| PDB=
}}

Spectrin repeats^[2] are found in several proteins involved in cytoskeletal structure. These include spectrin, alpha-actinin, dystrophin and more recently the plakin family. The spectrin repeat forms a three-helix bundle. These conform to the rules of the heptad repeat. Spectrin repeats give rise to linear proteins. This however may be due to sample bias in which linear and rigid structures are more amenable to crystallization. There are hints however, that some proteins harbouring spectrin repeats may also be flexible. This is most likely due to specifically evolved functional purposes.

Human proteins containing this domain

ACTN1; ACTN2; ACTN3; ACTN4; AKAP6; SYNE3; CATX-15; DMD;

DRP2; DST; KALRN; MACF1; MCF2L; SPTA1; SPTAN1;

SPTB; SPTBN1; SPTBN2; SPTBN4; SPTBN5; SYNE1; SYNE2;

TRIO; UTRN;

References

1. ^{{cite journal |vauthors=Pascual J, Pfuhl M, Walther D, Saraste M, Nilges M |title=Solution structure of the spectrin repeat: a left-handed antiparallel triple-helical coiled-coil |journal=J. Mol. Biol. |volume=273 |issue=3 |pages=740–51 |date=October 1997 |pmid=9356261 |doi=10.1006/jmbi.1997.1344 |url=}}
2. ^{{cite journal |vauthors=Harrison SC, Yan Y, Winograd E, Viel A, Cronin T, Branton D |title=Crystal structure of the repetitive segments of spectrin |journal=Science |volume=262 |issue=5142 |pages=2027–2030 |year=1993 |pmid=8266097 |doi=10.1126/science.8266097}}

{{cite journal|last=Jefferson|first=JJ|author2=Ciatto, C |author3=Shapiro, L |author4=Liem, RK |title=Structural analysis of the plakin domain of bullous pemphigoid antigen1 (BPAG1) suggests that plakins are members of the spectrin superfamily.|journal=Journal of Molecular Biology|year=2007|volume=366|issue=1|pages=244–57|pmid=17161423|doi=10.1016/j.jmb.2006.11.036|pmc=1850962}}
{{cite journal|last=Grum|first=VL|author2=Li, D |author3=MacDonald, RI |author4=Mondragón, A |title=Structures of two repeats of spectrin suggest models of flexibility.|journal=Cell|year=1999|volume=98|issue=4|pages=523–35|pmid=10481916|doi=10.1016/S0092-8674(00)81980-7}}

Human proteins containing this domain

References

Further reading