| 词条 | Synovial sarcoma, X breakpoint |
| 释义 |
They include:
The group also has several associated pseudogenes, and the interacting protein SSX2IP. The translocation t(X;18) creates a fusion of the SYT gene(at 18q11) with either SSX1 or SSX2 (both at Xp11). Neither SYT, nor the SSX proteins contain DNA-binding domains. Instead, they appear to be transcriptional regulators whose actions are mediated primarily through protein–protein interactions, with BRM in the case of SYT, and with Polycomb group repressors in the case of SSX. [2] References1. ^{{Cite journal |vauthors=Valmori D, Qian F, Ayyoub M, etal |title=Expression of synovial sarcoma X (SSX) antigens in epithelial ovarian cancer and identification of SSX-4 epitopes recognized by CD4+ T cells |journal=Clin. Cancer Res. |volume=12 |issue=2 |pages=398–404 |date=January 2006 |pmid=16428478 |doi=10.1158/1078-0432.CCR-05-1902 |url=http://clincancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=16428478}} {{Genetics-stub}}2. ^{{Cite journal | pmid = 11607825| year = 2001| author1 = Ladanyi| first1 = M| title = Fusions of the SYT and SSX genes in synovial sarcoma| journal = Oncogene| volume = 20| issue = 40| pages = 5755–62| doi = 10.1038/sj.onc.1204601}} 1 : Sarcoma |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。