| 释义 |
- Function
- See also
- References
- Further reading
{{Infobox_gene}}Taste receptor type 2 member 4 is a protein that in humans is encoded by the TAS2R4 gene.[1][2][3] Function This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception.[3] See alsoReferences1. ^{{cite journal | vauthors = Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS | title = A novel family of mammalian taste receptors | journal = Cell | volume = 100 | issue = 6 | pages = 693–702 | date = Apr 2000 | pmid = 10761934 | pmc = | doi = 10.1016/S0092-8674(00)80705-9 }}
2. ^{{cite journal | vauthors = Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ | title = T2Rs function as bitter taste receptors | journal = Cell | volume = 100 | issue = 6 | pages = 703–11 | date = Apr 2000 | pmid = 10761935 | pmc = | doi = 10.1016/S0092-8674(00)80706-0 }}
3. ^1 {{cite web | title = Entrez Gene: TAS2R4 taste receptor, type 2, member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50832| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | author = Kinnamon SC | title = A plethora of taste receptors | journal = Neuron | volume = 25 | issue = 3 | pages = 507–10 | year = 2000 | pmid = 10774719 | doi = 10.1016/S0896-6273(00)81054-5 }}
- {{cite journal | author = Margolskee RF | title = Molecular mechanisms of bitter and sweet taste transduction | journal = J. Biol. Chem. | volume = 277 | issue = 1 | pages = 1–4 | year = 2002 | pmid = 11696554 | doi = 10.1074/jbc.R100054200 }}
- {{cite journal | vauthors = Montmayeur JP, Matsunami H | title = Receptors for bitter and sweet taste | journal = Curr. Opin. Neurobiol. | volume = 12 | issue = 4 | pages = 366–71 | year = 2002 | pmid = 12139982 | doi = 10.1016/S0959-4388(02)00345-8 }}
- {{cite journal | author = Firestein S | title = The good taste of genomics | journal = Nature | volume = 404 | issue = 6778 | pages = 552–3 | year = 2000 | pmid = 10766221 | doi = 10.1038/35007167 }}
- {{cite journal | vauthors = Matsunami H, Montmayeur JP, Buck LB | title = A family of candidate taste receptors in human and mouse | journal = Nature | volume = 404 | issue = 6778 | pages = 601–4 | year = 2000 | pmid = 10766242 | doi = 10.1038/35007072 }}
- {{cite journal | vauthors = Ueda T, Ugawa S, Ishida Y, Shibata Y, Murakami S, Shimada S | title = Identification of coding single-nucleotide polymorphisms in human taste receptor genes involving bitter tasting | journal = Biochem. Biophys. Res. Commun. | volume = 285 | issue = 1 | pages = 147–51 | year = 2001 | pmid = 11437385 | doi = 10.1006/bbrc.2001.5136 }}
- {{cite journal | vauthors = Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ | title = Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways | journal = Cell | volume = 112 | issue = 3 | pages = 293–301 | year = 2003 | pmid = 12581520 | doi = 10.1016/S0092-8674(03)00071-0 }}
- {{cite journal | vauthors = Fischer A, Gilad Y, Man O, Pääbo S | title = Evolution of bitter taste receptors in humans and apes | journal = Mol. Biol. Evol. | volume = 22 | issue = 3 | pages = 432–6 | year = 2005 | pmid = 15496549 | doi = 10.1093/molbev/msi027 }}
- {{cite journal | vauthors = Go Y, Satta Y, Takenaka O, Takahata N | title = Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates | journal = Genetics | volume = 170 | issue = 1 | pages = 313–26 | year = 2006 | pmid = 15744053 | pmc = 1449719 | doi = 10.1534/genetics.104.037523 }}
{{refend}}{{NLM content}}{{G protein-coupled receptors|g3}}{{transmembranereceptor-stub}} 1 : G protein-coupled receptors |