| 词条 | Tetrindole |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 451925145 | IUPAC_name = 2,3,3a,4,5,6-Hexahydro-8-cyclohexyl-1H-pyrazino[3,2,1-j,k]carbazole | image = Tetrindole skeletal.svg | width = 110 | alt = | caption = | tradename = | Drugs.com = | MedlinePlus = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = | ATCvet = | ATC_prefix = None | ATC_suffix = | PubChem = 160020 | ChEBI_Ref = {{ebicite|changed|EBI}} | ChEBI = 77799 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | C=20 | H=26 | N=2 | molecular_weight = 294.43 g/mol | smiles = C1CCC(CC1)C2=CC3=C(C=C2)N4CCNC5C4=C3CCC5 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C20H26N2/c1-2-5-14(6-3-1)15-9-10-19-17(13-15)16-7-4-8-18-20(16)22(19)12-11-21-18/h9-10,13-14,18,21H,1-8,11-12H2 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = AUXCHYJDVJZEPG-UHFFFAOYSA-N | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 140675 }}Tetrindole was a drug candidate that functions by reversibly inhibiting monoamine oxidase A; it was first synthesized in Moscow in the early 1990s.[1] Tetrindole is similar in its chemical structure to pirlindole (Pyrazidol), and metralindole.[2] References1. ^{{cite journal|last1=Medvedev|first1=AE|last2=Kirkel|first2=AA|last3=Kamyshanskaya|first3=NS|last4=Moskvitina|first4=TA|last5=Axenova|first5=LN|last6=Gorkin|first6=VZ|last7=Andreeva|first7=NI|last8=Golovina|first8=SM|last9=Mashkovsky|first9=MD|title=Monoamine Oxidase Inhibition by Novel Antidepressant Tetrindole|journal=Biochemical Pharmacology|date=20 January 1994|volume=47|issue=2|pages=303–8|doi=10.1016/0006-2952(94)90021-3|pmid=8304974}} {{Antidepressants}}{{Monoamine metabolism modulators}}{{nervous-system-drug-stub}}2. ^{{cite journal|last1=Ramsay|first1=RR|last2=Gravestock|first2=MB|title=Monoamine Oxidases: to Inhibit or Not to Inhibit|journal=Mini Reviews in Medicinal Chemistry|date=March 2003|volume=3|issue=2|pages=129–36|pmid=12570845|doi=10.2174/1389557033405287}} 4 : Reversible inhibitors of MAO-A|Abandoned drugs|Monoamine oxidase inhibitors|Russian drugs |
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