| 词条 | Trapidil |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 448082882 | IUPAC_name = N,N-Diethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine | image = Trapidil.svg | width = 150 | tradename = Rocornal, Avantrin, Travisco | Drugs.com = {{drugs.com|international|trapidil}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = Not approved | legal_status = Rx-only | routes_of_administration = By mouth | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 15421-84-8 | ATC_prefix = C01 | ATC_suffix = DX11 | PubChem = 5531 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | UNII_Ref = {{fdacite|correct|FDA}} | UNII = EYG5Y6355E | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 5330 | C=10 | H=15 | N=5 | molecular_weight = 205.26 g/mol | smiles = CCN(CC)c1cc(nc2n1ncn2)C | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C10H15N5/c1-4-14(5-2)9-6-8(3)13-10-11-7-12-15(9)10/h6-7H,4-5H2,1-3H3 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = GSNOZLZNQMLSKJ-UHFFFAOYSA-N }}Trapidil is a vasodilator and an antiplatelet drug.[1][2] It also acts as an antagonist of platelet-derived growth factor.[3] References1. ^{{cite journal | last1 = Büyükafşar | first1 = K | last2 = Yazar | first2 = A | last3 = Düşmez | first3 = D | last4 = Oztürk | first4 = H | last5 = Polat | first5 = G | last6 = Levent | first6 = A | title = Effect of Trapidil, an Antiplatelet and Vasodilator Agent on Gentamicin-Induced Nephrotoxicity in Rats | journal = Pharmacological Research | date = October 2001 | volume = 44 | issue = 4 | pages = 321–8 | doi = 10.1006/phrs.2001.0864 | pmid = 11592868 }} {{Antithrombotics}}{{Vasodilators used in cardiac diseases}}{{Phosphodiesterase inhibitors}}{{cardiovascular-drug-stub}}2. ^{{cite journal | last1 = Liu | first1 = M | last2 = Sun | first2 = Q | last3 = Wang | first3 = Q | last4 = Wang | first4 = X | last5 = Lin | first5 = P | last6 = Yang | first6 = M | last7 = Yan | first7 = Y | title = Effect of Trapidil in Myocardial Ischemia-Reperfusion Injury in Rabbit | journal = Indian Journal of Pharmacology | date = March–April 2014 | volume = 46 | issue = 2 | pages = 207–10 | doi = 10.4103/0253-7613.129320 | pmid = 24741195 | pmc = 3987192}} 3. ^{{cite journal | last1 = Maresta | first1 = A | last2 = Balducelli | first2 = M | last3 = Cantini | first3 = L | last4 = Casari | first4 = A | last5 = Chioin | first5 = R | last6 = Fabbri | first6 = M | last7 = Fontanelli | first7 = A | last8 = Monici Preti | first8 = PA | last9 = Repetto | first9 = S | last10 = De Servi | first10 = S | title = Trapidil (triazolopyrimidine), a Platelet-Derived Growth Factor Antagonist, Reduces Restenosis After Percutaneous Transluminal Coronary Angioplasty. Results of the Randomized, Double-Blind STARC Study | journal = Circulation | date = December 1994 | volume = 90 | issue = 6 | pages = 2710–5 | pmid = 7994812 | doi=10.1161/01.cir.90.6.2710}} 3 : Vasodilators|Phosphodiesterase inhibitors|Triazolopyrimidines |
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