| 释义 |
- References
- Further reading
{{Infobox_gene}}Trefoil factor 2 is a protein that in humans is encoded by the TFF2 gene.[1][2][3]Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.[3] References1. ^{{cite journal |vauthors=Tomasetto C, Rockel N, Mattei MG, Fujita R, Rio MC | title = The gene encoding the human spasmolytic protein (SML1/hSP) is in 21q 22.3, physically linked to the homologous breast cancer marker gene BCEI/pS2 | journal = Genomics | volume = 13 | issue = 4 | pages = 1328–30 |date=Sep 1992 | pmid = 1505966 | pmc = | doi =10.1016/0888-7543(92)90059-2 }}
2. ^{{cite journal |vauthors=Gott P, Beck S, Machado JC, Carneiro F, Schmitt H, Blin N | title = Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression | journal = Eur J Hum Genet | volume = 4 | issue = 6 | pages = 308–15 |date=May 1997 | pmid = 9043862 | pmc = | doi = }}
3. ^1 {{cite web | title = Entrez Gene: TFF2 trefoil factor 2 (spasmolytic protein 1)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7032| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Advenier C, Lagente V, Boichot E |title=The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough. |journal=Eur. Respir. J. |volume=10 |issue= 8 |pages= 1892–906 |year= 1997 |pmid= 9272936 |doi=10.1183/09031936.97.10081892 }}
- {{cite journal |vauthors=Langer G, Jagla W, Behrens-Baumann W, etal |title=Ocular TFF-peptides: new mucus-associated secretory products of conjunctival goblet cells. |journal=Adv. Exp. Med. Biol. |volume=506 |issue= Pt A |pages= 313–6 |year= 2003 |pmid= 12613926 |doi= }}
- {{cite journal |vauthors=Tomasetto C, Rio MC, Gautier C, etal |title=hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma. |journal=EMBO J. |volume=9 |issue= 2 |pages= 407–14 |year= 1990 |pmid= 2303034 |doi= | pmc=551681 }}
- {{cite journal |vauthors=Bhogal N, Donnelly D, Findlay JB |title=The ligand binding site of the neurokinin 2 receptor. Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor. |journal=J. Biol. Chem. |volume=269 |issue= 44 |pages= 27269–74 |year= 1994 |pmid= 7961636 |doi= }}
- {{cite journal |vauthors=Hanby AM, Poulsom R, Singh S, etal |title=Spasmolytic polypeptide is a major antral peptide: distribution of the trefoil peptides human spasmolytic polypeptide and pS2 in the stomach. |journal=Gastroenterology |volume=105 |issue= 4 |pages= 1110–6 |year= 1993 |pmid= 8405856 |doi= }}
- {{cite journal |vauthors=Itoh H, Tomita M, Uchino H, etal |title=cDNA cloning of rat pS2 peptide and expression of trefoil peptides in acetic acid-induced colitis. |journal=Biochem. J. |volume=318 |issue= 3|pages= 939–44 |year= 1996 |pmid= 8836141 |doi= | pmc=1217708 }}
- {{cite journal |vauthors=May FE, Westley BR |title=Close physical linkage of the genes encoding the pNR-2/pS2 protein and human spasmolytic protein (hSP). |journal=Hum. Genet. |volume=99 |issue= 3 |pages= 303–7 |year= 1997 |pmid= 9050913 |doi=10.1007/s004390050362 }}
- {{cite journal |vauthors=Seib T, Blin N, Hilgert K, etal |title=The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3. |journal=Genomics |volume=40 |issue= 1 |pages= 200–2 |year= 1997 |pmid= 9070946 |doi= 10.1006/geno.1996.4511 }}
- {{cite journal |vauthors=Kayademir T, Silva Edos S, Pusch C, etal |title=A novel 25 bp tandem repeat within the human trefoil peptide gene TFF2 in 21q22.3: polymorphism and mammalian evolution. |journal=Eur. J. Hum. Genet. |volume=6 |issue= 2 |pages= 121–8 |year= 1998 |pmid= 9781055 |doi= 10.1038/sj.ejhg.5200166 }}
- {{cite journal |vauthors=Brunelleschi S, Bordin G, Colangelo D, Viano I |title=Tachykinin receptors on human monocytes: their involvement in rheumatoid arthritis. |journal=Neuropeptides |volume=32 |issue= 3 |pages= 215–23 |year= 1999 |pmid= 10189055 |doi=10.1016/S0143-4179(98)90040-3 }}
- {{cite journal |vauthors=May FE, Semple JI, Newton JL, Westley BR |title=The human two domain trefoil protein, TFF2, is glycosylated in vivo in the stomach. |journal=Gut |volume=46 |issue= 4 |pages= 454–9 |year= 2000 |pmid= 10716671 |doi=10.1136/gut.46.4.454 | pmc=1727891 }}
- {{cite journal |vauthors=Hattori M, Fujiyama A, Taylor TD, etal |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }}
- {{cite journal |vauthors=Berry A, Scott HS, Kudoh J, etal |title=Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region. |journal=Genomics |volume=68 |issue= 1 |pages= 22–9 |year= 2001 |pmid= 10950923 |doi= 10.1006/geno.2000.6253 }}
- {{cite journal |vauthors=Bulitta CJ, Fleming JV, Raychowdhury R, etal |title=Autoinduction of the trefoil factor 2 (TFF2) promoter requires an upstream cis-acting element. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 1 |pages= 366–74 |year= 2002 |pmid= 12054609 |doi= 10.1016/S0006-291X(02)00199-7 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Hu GY, Yu BP, Dong WG, etal |title=Expression of TFF2 and Helicobacter pylori infection in carcinogenesis of gastric mucosa. |journal=World J. Gastroenterol. |volume=9 |issue= 5 |pages= 910–4 |year= 2003 |pmid= 12717829 |doi= }}
{{refend}}{{gene-21-stub}} |