Van Helmont is a Dutch and Flemish surname. It may refer to:

• Jan van Helmont (1650 – between 1714 and 1734), a Flemish painter
• Jan Baptist van Helmont (1580 - 1644), a Flemish chemist, physiologist, and physician
• Franciscus Mercurius van Helmont (1614 - 1699) a Flemish alchemist and writer, the son of Jan Baptist van Helmont
• Mattheus van Helmont (1623 - after 1685), a Flemish painter
• Zeger Jacob van Helmont (1683 - 1726), a Flemish painter

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