| 释义 |
- References
- Further reading
{{Underlinked|date=June 2016}}{{Infobox_gene}}Wiskott-Aldrich syndrome protein family member 3 is a protein that in humans is encoded by the WASF3 gene.[1][2]This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.[2] References1. ^{{cite journal | vauthors = Suetsugu S, Miki H, Takenawa T | title = Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex | journal = Biochem Biophys Res Commun | volume = 260 | issue = 1 | pages = 296–302 |date=Jul 1999 | pmid = 10381382 | pmc = | doi = 10.1006/bbrc.1999.0894 }}
2. ^1 {{cite web | title = Entrez Gene: WASF3 WAS protein family, member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10810| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | author=Jones GE |title=Cellular signaling in macrophage migration and chemotaxis |journal=J. Leukoc. Biol. |volume=68 |issue= 5 |pages= 593–602 |year= 2000 |pmid= 11073096 |doi= }}
- {{cite journal |vauthors=Nakajima D, Okazaki N, Yamakawa H, etal |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 }}
- {{cite journal |vauthors=Schott DR, Chang JN, Deng G, etal |title=A candidate tumor suppressor gene in human breast cancers |journal=Cancer Res. |volume=54 |issue= 6 |pages= 1393–6 |year= 1994 |pmid= 8137235 |doi= }}
- {{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
- {{cite journal | vauthors=Bear JE, Rawls JF, Saxe CL |title=SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development |journal=J. Cell Biol. |volume=142 |issue= 5 |pages= 1325–35 |year= 1998 |pmid= 9732292 |doi=10.1083/jcb.142.5.1325 | pmc=2149354 }}
- {{cite journal |vauthors=Nagase T, Ishikawa K, Suyama M, etal |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=5 |issue= 6 |pages= 355–64 |year= 1999 |pmid= 10048485 |doi=10.1093/dnares/5.6.355 }}
- {{cite journal | vauthors=Marchand JB, Kaiser DA, Pollard TD, Higgs HN |title=Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex |journal=Nat. Cell Biol. |volume=3 |issue= 1 |pages= 76–82 |year= 2001 |pmid= 11146629 |doi= 10.1038/35050590 }}
- {{cite journal | vauthors=Millard TH, Machesky LM |title=The Wiskott-Aldrich syndrome protein (WASP) family |journal=Trends Biochem. Sci. |volume=26 |issue= 3 |pages= 198–9 |year= 2001 |pmid= 11246027 |doi=10.1016/S0968-0004(01)01788-1 }}
- {{cite journal |vauthors=Sossey-Alaoui K, Su G, Malaj E, etal |title=WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma |journal=Oncogene |volume=21 |issue= 38 |pages= 5967–74 |year= 2002 |pmid= 12185600 |doi= 10.1038/sj.onc.1205734 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal | vauthors=Sossey-Alaoui K, Head K, Nowak N, Cowell JK |title=Genomic organization and expression profile of the human and mouse WAVE gene family |journal=Mamm. Genome |volume=14 |issue= 5 |pages= 314–22 |year= 2003 |pmid= 12856283 |doi= 10.1007/s00335-002-2247-7 }}
- {{cite journal |vauthors=Dunham A, Matthews LH, Burton J, etal |title=The DNA sequence and analysis of human chromosome 13 |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 | pmc=2665288 }}
- {{cite journal |vauthors=Oda A, Miki H, Wada I, etal |title=WAVE/Scars in platelets |journal=Blood |volume=105 |issue= 8 |pages= 3141–8 |year= 2005 |pmid= 15280206 |doi= 10.1182/blood-2003-04-1319 }}
- {{cite journal |vauthors=Kashiwagi H, Shiraga M, Kato H, etal |title=Expression and subcellular localization of WAVE isoforms in the megakaryocyte/platelet lineage |journal=J. Thromb. Haemost. |volume=3 |issue= 2 |pages= 361–8 |year= 2005 |pmid= 15670045 |doi= 10.1111/j.1538-7836.2004.01082.x }}
- {{cite journal | vauthors=Stovold CF, Millard TH, Machesky LM |title=Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2 |journal=BMC Cell Biol. |volume=6 |issue=1 |pages= 11 |year= 2006 |pmid= 15752430 |doi= 10.1186/1471-2121-6-11 | pmc=555569 }}
- {{cite journal | vauthors=Sossey-Alaoui K, Li X, Ranalli TA, Cowell JK |title=WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-kinase |journal=J. Biol. Chem. |volume=280 |issue= 23 |pages= 21748–55 |year= 2005 |pmid= 15826941 |doi= 10.1074/jbc.M500503200 }}
- {{cite journal |vauthors=Sossey-Alaoui K, Ranalli TA, Li X, etal |title=WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression |journal=Exp. Cell Res. |volume=308 |issue= 1 |pages= 135–45 |year= 2005 |pmid= 15907837 |doi= 10.1016/j.yexcr.2005.04.011 }}
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