WFME may refer to:

• WFME (AM), a radio station (1560 AM) licensed to serve New York City, New York, United States
• WFME-FM, a radio station (106.3 FM) licensed to serve Mount Kisco, New York
• WNYJ-TV, a television station (channel 29 digital/66 virtual) licensed to serve West Milford, New Jersey, United States, which held the call sign WFME-TV from 1988 to 2013
• WNSH, a radio station (94.7 FM) licensed to serve Newark, New Jersey, which held the call sign WFME from 1964 to January 11, 2013.

• Minnesota State Highway 277
• Minnesota State Highway 28
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• Minnesota State Highway 29
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