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| Name = 23S rRNA (uridine2552-2'-O)-methyltransferase
| EC_number = 2.1.1.166
| CAS_number =
| IUBMB_EC_number = 2/1/1/166
| GO_code =
| image =
| width =
| caption =
}}23S rRNA (uridine2552-2'-O)-methyltransferase ({{EC number|2.1.1.166}}, Um(2552) 23S ribosomal RNA methyltransferase, heat shock protein RrmJ, RrmJ, FTSJ, Um2552 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (uridine2552-2'-O-)-methyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
S-adenosyl-L-methionine + uridine2552 in 23S rRNAS-adenosyl-L-homocysteine + 2'-O-methyluridine2552 in 23S rRNA
The enzyme catalyses the 2'-O-methylation of the universally conserved U2552 in the A loop of 23S rRNA.
References
1. ^{{cite journal | vauthors = Caldas T, Binet E, Bouloc P, Costa A, Desgres J, Richarme G | title = The FtsJ/RrmJ heat shock protein of Escherichia coli is a 23 S ribosomal RNA methyltransferase | journal = The Journal of Biological Chemistry | volume = 275 | issue = 22 | pages = 16414–9 | date = June 2000 | pmid = 10748051 | doi = 10.1074/jbc.M001854200 }}
2. ^{{cite journal | vauthors = Hager J, Staker BL, Bugl H, Jakob U | title = Active site in RrmJ, a heat shock-induced methyltransferase | journal = The Journal of Biological Chemistry | volume = 277 | issue = 44 | pages = 41978–86 | date = November 2002 | pmid = 12181314 | doi = 10.1074/jbc.M205423200 }}
3. ^{{cite journal | vauthors = Hager J, Staker BL, Jakob U | title = Substrate binding analysis of the 23S rRNA methyltransferase RrmJ | journal = Journal of Bacteriology | volume = 186 | issue = 19 | pages = 6634–42 | date = October 2004 | pmid = 15375145 | pmc = 516604 | doi = 10.1128/JB.186.19.6634-6642.2004 }}
4. ^{{cite journal | vauthors = Bügl H, Fauman EB, Staker BL, Zheng F, Kushner SR, Saper MA, Bardwell JC, Jakob U | title = RNA methylation under heat shock control | journal = Molecular Cell | volume = 6 | issue = 2 | pages = 349–60 | date = August 2000 | pmid = 10983982 | doi = 10.1016/S1097-2765(00)00035-6 }}
2. ^{{cite journal | vauthors = Hager J, Staker BL, Bugl H, Jakob U | title = Active site in RrmJ, a heat shock-induced methyltransferase | journal = The Journal of Biological Chemistry | volume = 277 | issue = 44 | pages = 41978–86 | date = November 2002 | pmid = 12181314 | doi = 10.1074/jbc.M205423200 }}
3. ^{{cite journal | vauthors = Hager J, Staker BL, Jakob U | title = Substrate binding analysis of the 23S rRNA methyltransferase RrmJ | journal = Journal of Bacteriology | volume = 186 | issue = 19 | pages = 6634–42 | date = October 2004 | pmid = 15375145 | pmc = 516604 | doi = 10.1128/JB.186.19.6634-6642.2004 }}
4. ^{{cite journal | vauthors = Bügl H, Fauman EB, Staker BL, Zheng F, Kushner SR, Saper MA, Bardwell JC, Jakob U | title = RNA methylation under heat shock control | journal = Molecular Cell | volume = 6 | issue = 2 | pages = 349–60 | date = August 2000 | pmid = 10983982 | doi = 10.1016/S1097-2765(00)00035-6 }}
External links
- {{MeshName|23S+rRNA+(uridine2552-2'-O)-methyltransferase}}
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