| 词条 | Altechromone A |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 456682023 | Reference = [1] | ImageFile = AltechromoneA.png | IUPACName = 7-Hydroxy-2,5-dimethyl-4H-chromen-4-one | OtherNames = Altechromone A |Section1={{Chembox Identifiers | CASNo = 38412-47-4 | CASNo_Ref = {{cascite|changed|??}} | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 509319 | PubChem = 5316891 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 4475859 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C11H10O3/c1-6-3-8(12)5-10-11(6)9(13)4-7(2)14-10/h3-5,12H,1-2H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = CRNGFKXWIYTEPH-UHFFFAOYSA-N | SMILES = O=C\\1c2c(O/C(=C/1)C)cc(O)cc2C | InChI = InChI=1S/C11H10O3/c1-6-3-8(12)5-10-11(6)9(13)4-7(2)14-10/h3-5,12H,1-2H3 |Section2={{Chembox Properties | C=11 | H=10 | O=3 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} Altechromone A is a chromone derivative. To date, it has been isolated from plant families such as Polygonaceae, Lamiaceae, Fabaceae, and Hypericaceae. IsolationAltechromone A was isolated from an Alternaria sp. in 1992. It has since been isolated from fungi species such as Hypoxium trancatum, Ascomycota sp., and Alternaria brassicicola. Researchers have come to the conclusion that Altechromone A is a common fungal metabolite with its origin in endophytic fungi.[2] Potential usesFor thousands of years, humans have used endophytic species in traditional medicines. Since Louis Pasteur began investigating microbes, science has further revealed the potential benefits of these compounds.[3] Researchers noted that this compound demonstrates both root growth promotion and inhibits bacterial production. Penicillin and other antibiotics effectively treated microbial infections. However, antibiotic misuse has resulted in resistance of pathogens to antimicrobial agents. Altechromone A could provide a source of antimocrobial agents that microbes have yet to develop a resistance to.[4] In addition, the compound could possess anti-tumor capabilities thus yielding more potential medical applications.[5] References1. ^{{cite web|title=2,5-Dimethyl-7-hydroxy chromone|url=http://www.chemspider.com/Chemical-Structure.4475859.html|work=ChemSpider|publisher=Royal Society of Chemistry|accessdate=April 18, 2011}} 2. ^{{cite journal|last=Konigs|first=P.|author2=B. Rinker |author3=L. Maus |author4=M. Nieger |author5=J. Rheinheimer |author6=S. R. Waldvogel |title=Structural Revision and Synthesis of Altechromone A|journal=Journal of Natural Products|date=November 17, 2010|volume=73|series=12|pages=2064–2066|doi=10.1021/1005604|doi-broken-date=2019-02-12}} 3. ^{{cite journal|last=Strobel|first=Gary|author2=Bryn Daisy|title=Bioprospecting for Microbial Endophytes and Their Natural Products|journal=Microbiology and Molecular Biology Reviews|date=December 2003|volume=67|series=4|pages=1092–2172|doi=10.1128/MMBR.67.4.491-502.2003|pmid=14665674|issue=4|pmc=309047}} 4. ^{{cite journal|last=Gu|first=Wen|title=Bioactive metabolites from Alternaria brassicicola ML-PO8, an endophytic funus residing in Malus halliana|journal=World J Microbial Technology|date=May 23, 2009|doi=10.1007/s11274-009-0062-y|volume=25|issue=9|pages=1677–1683}} 5. ^{{cite journal|last=Gu|first=W.|author2=H. M. Ge |author3=Y. C. Song |author4=H. Din |author5=H. L. Zhu |author6=X. A. Zhao |author7=R. X. Tran |title=Cytotoxic Benzo[j]fluoranthene Metabolites from Hypoxylon truncatum IFB-18, and Endophyte of Artemisia annua|journal=Journal of Natural Products|date=December 24, 2006|volume=70|series=1|pages=114–117|doi=10.1021/np0604127 |issue=1 |pmid=17253861}} 1 : Chromones |
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