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| Name = Arsenite methyltransferase
| EC_number = 2.1.1.137
| CAS_number = 167140-41-2
| IUBMB_EC_number = 2/1/1/137
| GO_code =
| image =
| width =
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}}Arsenite methyltransferase ({{EC number|2.1.1.137}}, S-adenosyl-L-methionine:arsenic(III) methyltransferase, S-adenosyl-L-methionine:methylarsonite As-methyltransferase, methylarsonite methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:arsenite As-methyltransferase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
(1) S-adenosyl-L-methionine + arseniteS-adenosyl-L-homocysteine + methylarsonate
(2) S-adenosyl-L-methionine + methylarsonite
An enzyme of the biotransformation pathway that forms dimethylarsinate from inorganic arsenite and arsenate.
References
1. ^{{cite journal | vauthors = Zakharyan RA, Aposhian HV | title = Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase | journal = Chemical Research in Toxicology | volume = 12 | issue = 12 | pages = 1278–83 | date = December 1999 | pmid = 10604879 | doi = 10.1021/tx9901231 }}
2. ^{{cite journal | vauthors = Zakharyan RA, Ayala-Fierro F, Cullen WR, Carter DM, Aposhian HV | title = Enzymatic methylation of arsenic compounds. VII. Monomethylarsonous acid (MMAIII) is the substrate for MMA methyltransferase of rabbit liver and human hepatocytes | journal = Toxicology and Applied Pharmacology | volume = 158 | issue = 1 | pages = 9–15 | date = July 1999 | pmid = 10387927 | doi = 10.1006/taap.1999.8687 }}
3. ^{{cite journal | vauthors = Zakharyan RA, Wildfang E, Aposhian HV | title = Enzymatic methylation of arsenic compounds. III. The marmoset and tamarin, but not the rhesus, monkeys are deficient in methyltransferases that methylate inorganic arsenic | journal = Toxicology and Applied Pharmacology | volume = 140 | issue = 1 | pages = 77–84 | date = September 1996 | pmid = 8806872 | doi = 10.1006/taap.1996.0199 }}
4. ^{{cite journal | vauthors = Zakharyan R, Wu Y, Bogdan GM, Aposhian HV | title = Enzymatic methylation of arsenic compounds: assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver | journal = Chemical Research in Toxicology | volume = 8 | issue = 8 | pages = 1029–38 | date = December 1995 | pmid = 8605285 | doi = 10.1021/tx00050a006 }}
5. ^{{cite journal | vauthors = Lin S, Shi Q, Nix FB, Styblo M, Beck MA, Herbin-Davis KM, Hall LL, Simeonsson JB, Thomas DJ | title = A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol | journal = The Journal of Biological Chemistry | volume = 277 | issue = 13 | pages = 10795–803 | date = March 2002 | pmid = 11790780 | doi = 10.1074/jbc.M110246200 }}
2. ^{{cite journal | vauthors = Zakharyan RA, Ayala-Fierro F, Cullen WR, Carter DM, Aposhian HV | title = Enzymatic methylation of arsenic compounds. VII. Monomethylarsonous acid (MMAIII) is the substrate for MMA methyltransferase of rabbit liver and human hepatocytes | journal = Toxicology and Applied Pharmacology | volume = 158 | issue = 1 | pages = 9–15 | date = July 1999 | pmid = 10387927 | doi = 10.1006/taap.1999.8687 }}
3. ^{{cite journal | vauthors = Zakharyan RA, Wildfang E, Aposhian HV | title = Enzymatic methylation of arsenic compounds. III. The marmoset and tamarin, but not the rhesus, monkeys are deficient in methyltransferases that methylate inorganic arsenic | journal = Toxicology and Applied Pharmacology | volume = 140 | issue = 1 | pages = 77–84 | date = September 1996 | pmid = 8806872 | doi = 10.1006/taap.1996.0199 }}
4. ^{{cite journal | vauthors = Zakharyan R, Wu Y, Bogdan GM, Aposhian HV | title = Enzymatic methylation of arsenic compounds: assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver | journal = Chemical Research in Toxicology | volume = 8 | issue = 8 | pages = 1029–38 | date = December 1995 | pmid = 8605285 | doi = 10.1021/tx00050a006 }}
5. ^{{cite journal | vauthors = Lin S, Shi Q, Nix FB, Styblo M, Beck MA, Herbin-Davis KM, Hall LL, Simeonsson JB, Thomas DJ | title = A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol | journal = The Journal of Biological Chemistry | volume = 277 | issue = 13 | pages = 10795–803 | date = March 2002 | pmid = 11790780 | doi = 10.1074/jbc.M110246200 }}
External links
- {{MeshName|Arsenite+methyltransferase}}
1 : EC 2.1.1
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