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词条 ATUM
释义

  1. The company

  2. Research tools

  3. Partnerships

  4. References

  5. External links

{{COI|date=February 2019}}{{Infobox company
| name = ATUM
| logo = ATUM logo.png
| type = Private
| founders = Sridhar Govindarajan, Claes Gustafsson, Jeremy Minshull, Jon Ness
| area_served =
| key_people =
| industry = Biotechnology
| genre =
| products = Gene Synthesis, Protein Engineering, Protein Production, Bioinformatics, Cell line development, Leap-In transposases
| revenue =
| operating_income =
| net_income =
| owner =
| num_employees =
| parent =
| divisions =
| subsid =
| footnotes =
| vector_logo =
| foundation = 2003
| location_city = Newark, California
| location_country = United States
| location =
| origins =
| slogan =
| homepage = www.atum.bio
| dissolved =
}}

ATUM is an American biotechnology company which provides tools and solutions for the life sciences, from design and synthesis of optimized DNA to protein production and GMP cell line development.

The company

ATUM (formerly DNA2.0) was founded in 2003, in Menlo Park, California. The company is privately held[1] and continues to have all research, development and production in California, currently in their 50,000 sq ft Newark facility.[2] It began and continues as a gene synthesis and protein engineering provider to academia, government and the pharmaceutical, chemical, agricultural and biotechnology industries. Gene Synthesis rapidly replaced molecular cloning for many academic and corporate labs, as "foundries for the biotechnology age" allowing made-to-order genes for biological research.[3]

DNA2.0 was featured on the PBS show Nova ScienceNow[4] to show how genes are created synthetically in a lab. In 2008, the company supplied some of the DNA stretches used to create a synthetic bacterial genome.[5]

Dan Rather Reports included DNA2.0 in their episode on Synthetic Biology[6] and how it is solving "some of the most important problems facing the world."[6]

In 2009, The Scientist named the codon design algorithms[7] (now trademarked as GeneGPS) developed by DNA2.0 as one of the Top 10 Innovations of the year for Life Sciences.[8] ATUM developed the Electra Vector System, a universal cloning system that utilizes the type IIS restriction enzyme SapI and T4 DNA ligase in a single-tube reaction.[9] ATUM has made some molecular components, such as synthetic fluorescent proteins, available in open-access collections of DNA parts (BioBricks Foundation).[10] Atum is a founding member of the International Gene Synthesis Consortium (IGSC) to promote biosecurity in the gene-synthesis industry.[11][12] There are over 1,200[13] published scientific articles using DNA2.0 products and/or services, of which 44[14] include company employees as an author(s).

Research tools

  • Gene Designer is a free bioinformatics software package.[15][16] It is used by molecular biologists to design,[17] clone and validate genetic sequences.[18]
  • A free gRNA design tool with scoring algorithms for CRISPR.
  • DNA ATLAS is a free plasmid mapping tool to show features such as promoters, markers, restriction sites and open reading frames in any DNA vector sequence.
  • The online Bioinformatics toolbox was selected as a Best of the Web by Genetic Engineering News.[19]

Partnerships

  • The Perelman School of Medicine at the University of Pennsylvania will use the GeneGPS technology developed by ATUM primarily to support the Gene Therapy Program’s work on HIV-1 vaccine development by optimizing in vivo protein expression.[20][21]
  • The Infection and Immunity Research Centre at St. George’s, University of London and Atum partnered to develop plant-based pharmaceuticals.[22]
  • Adimab LLC. and ATUM employ an alliance in the area of antibody discovery and biomanufacturing via the design and construction of antibody libraries.
  • Cytovance Biologics utilizes GeneGPS from ATUM as part of their Keystone Expression System for microbial strain development for successful biomanufacturing.
  • Archer Daniels Midland Company applies ATUM's proprietary protein engineering technology, ProteinGPS, to ADM’s industrial enzyme engineering processes.[23]
  • ATUM is a sponsor of BioBuilder, a resource for hands-on activities and informative animations on synthetic biology for middle school and high school students and teachers; founded by Dr. Natalie Kuldell at MIT.

References

1. ^{{cite news | last =Duan | first =Mary | title =Gene synthesis: It’s no strain for DNA 2.0 | newspaper =Silicon Valley Business Journal | location = San Jose, CA | date =October 18, 2009 | url =http://www.bizjournals.com/sanjose/stories/2009/10/19/focus1.html}}
2. ^{{cite web|title=DNA2.0 Builds State of the Art Bioproduction Facility in Newark, California|url=http://markets.financialcontent.com/mng-ba.mercurynews/news/read/31760923/DNA2.0_Builds_State_of_the_Art_Bioproduction_Facility_in_Newark|website=MercuryNews.com|publisher=The San Jose Mercury News|accessdate=22 March 2016}}
3. ^{{cite news | last = Pollack | title = How Do You Like Your Genes? Biofabs Take Orders | newspaper = The New York Times | location = New York | date = September 12, 2007 | url = https://www.nytimes.com/2007/09/12/technology/techspecial/12gene.html?_r=1&oref=slogin}}
4. ^{{cite episode | title=Artificial Life | series=Nova ScienceNow | url=https://www.youtube.com/watch?v=nBmxkZEKCi0 | network=PBS | airdate=October 18, 2005}}
5. ^{{cite news | last = Pollack | title = Scientists Take New Step Toward Man-Made Life | newspaper = The New York Times | location = New York | date = January 24, 2008 | url = https://www.nytimes.com/2008/01/24/science/24cnd-genome.html?scp=1&sq=Scientists%20Take%20New%20Step%20Toward%20Man&st=cse&_r=0 }}
6. ^1 {{cite episode| title = Cutting Edge| series = Dan Rather Reports| network = AXS TV | url=http://www.axs.tv/news-and-docs/cutting-edge-february-5-2013/ | airdate = April 30, 2013}}
7. ^{{cite journal | last = Welch | last2 = Govindarajan | last3 = Ness | last4 = Villalobos | last5 = Gurney | last6 = Minshull | last7 = Gustafsson | title = Design parameters to control synthetic gene expression in Escherichia coli. | journal = PLOS ONE | volume = 4 | issue = 9 | pages =e7002 | date =September 14, 2009 | url =http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0007002 | doi =10.1371/journal.pone.0007002 | pmid =19759823 | pmc =2736378 }}
8. ^{{cite journal | title = 2009 Top 10 Innovations | journal = The Scientist | volume = 23 | issue=12 | pages = 41–52 | date = December 1, 2009}}
9. ^{{Citation | last = Whitman | last2=Gore | last3=Ness | last4=Theodorou | last5=Minshull | title = Rapid, Scarless Cloning of Gene Fragments Using SapI, T4 DNA Ligase and the DNA2.0 Electra Vector System | journal = NEB Expressions | volume = II | pages = 8 | url=https://www.neb.com/~/media/NebUs/Files/Expressions/Expressions_IssueII_0613.pdf | date = June 2013 }}
10. ^{{cite journal | last1 = Ledford | first1 = Heidi | title = Bioengineers Look Beyond Patents | journal = Nature | volume = 499 | pages = 16–17 | publisher = Macmillan Publishers Limited | date = July 4, 2013 | url = http://www.nature.com/news/bioengineers-look-beyond-patents-1.13320 | doi = 10.1038/499016a | pmid=23823774}}
11. ^{{cite journal | last = Hayden | first = Erika Check | title = Gene-makers form security coalition | journal = Nature | date = November 18, 2009 | url=http://www.nature.com/news/2009/091118/full/news.2009.1095.html | doi=10.1038/news.2009.1095 }}
12. ^{{citation | title = Gene-Synthesis Firms Set Up Biosecurity Protocol | journal = Genetic Engineering & Biotechnology News | date = November 18, 2009 | url = http://www.genengnews.com/gen-news-highlights/gene-synthesis-firms-set-up-biosecurity-protocol/68850005/}}
13. ^{{cite web | title = Literature Database Search All | url = https://www.dna20.com/resources/literature-database?ldb_year=0-3000 | date = April 29, 2016}}
14. ^{{cite web | title = Literature Database Search Author Affiliation:DNA2.0 | url = https://www.dna20.com/resources/literature-database?ldb_affiliation=DNA | date = April 29, 2016}}
15. ^{{cite journal |doi=10.1186/1471-2105-7-285 |year=2006 |last1=Villalobos |first1=Alan |last2=Ness |first2=Jon E |last3=Gustafsson |first3=Claes |last4=Minshull |first4=Jeremy |last5=Govindarajan |first5=Sridhar |journal=BMC Bioinformatics |volume=7 |pages=285 |pmid=16756672 |title=Gene Designer: A synthetic biology tool for constructing artificial DNA segments |pmc=1523223}}
16. ^{{cite journal |doi=10.1007/978-1-61779-564-0_15 |title=In Silico Design of Functional DNA Constructs |journal=Gene Synthesis |series=Methods in Molecular Biology |year=2012 |last1=Villalobos |first1=Alan |last2=Welch |first2=Mark |last3=Minshull |first3=Jeremy |isbn=978-1-61779-563-3 |volume=852 |pmid=22328435 |pages=197–213}}
17. ^{{cite journal |pmid=21601673 |year=2011 |last1=Welch |first1=M |last2=Villalobos |first2=A |last3=Gustafsson |first3=C |last4=Minshull |first4=J |title=Designing genes for successful protein expression |volume=498 |pages=43–66 |doi=10.1016/B978-0-12-385120-8.00003-6 |journal=Methods in Enzymology}}
18. ^{{cite journal | last=Dance | first = Amber | url=http://www.the-scientist.com/?articles.view/articleNo/32275/title/Move-Over--Mother-Nature/ | journal=The Scientist | date=July 1, 2012 | title=Mover Over, Mother Nature.}}
19. ^{{Cite journal | title = Best of the Web | journal = Genetic Engineering News | date = April 15, 2007 }}
20. ^{{cite journal | journal=GEN | date=November 14, 2012 | url=http://www.genengnews.com/gen-news-highlights/optimizing-b-gene-b-b-expression-b-with-dna2-0-technology/81247634/ | title= Optimizing Gene Expression with DNA2.0 Technology.}}
21. ^{{Citation | last =McEnery | first =Regina | title =Delivering the DNA | journal = VAX The Bulletin on AIDS Vaccine Research | date = February 4, 2013 | volume=11 | issue = 1 | url =http://www.vaxreport.org/Back-Issues/Pages/Delivering-the-DNA.aspx}}
22. ^{{cite journal | journal=Vaccine News | date=December 24, 2013 | last=Cohen | first=Bryan | url=http://vaccinenewsdaily.com/medical_countermeasures/329037-dna2-0-announces-biopharmaceutical-partnership-with-st-georges/ | title=DNA2.0 Announces Biopharmaceutical Partnership with St. George's }}
23. ^{{cite news | newspaper=San Jose Mercury News | date=November 17, 2014 | location=San Jose, CA | url=http://markets.financialcontent.com/mng-ba.mercurynews/news/read/28924252/ADM_and_DNA2.0_Enter_Into_Protein_Engineering_Technology_Access_and_Service_Agreement | title= ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement.}}

External links

  • [https://www.atum.bio www.atum.bio]
  • [https://www.atum.bio/resources/tools/gene-designer GeneDesigner]

6 : Research support companies|Biotechnology companies of the United States|Technology companies based in the San Francisco Bay Area|Companies based in Silicon Valley|Biotechnology companies established in 2003|2003 establishments in California
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