| Ministry | Incumbent | | President of South Sudan | Salva Kiir Mayardit |
| First Vice President of South Sudan | Taban Deng Gai[2] |
| Vice President of South Sudan | James Wani Igga |
| Minister in the Office of the President | Mayiik Ayii Deng |
| Minister of Agriculture and Forestry | Onyoti Adigo Nyikwec |
| Minister of Animal Resources and Fisheries | Kon Ngu |
| Minister of Cabinet Affairs | Martin Elia Lomuro |
| Minister of Commerce, Industry and Investment | Dr. Moses Hasan Ayet |
| Minister of Culture, Youth and Sports | Dr. Nadia Arop Dudi |
| Minister of Defence and Veterans Affairs | Gen. Kuol Manyang Juuk |
| Minister of Electricity and Dams | Dr. Dhieu Mathok Diing |
| Minister of Environment | Josephine Napon |
| Minister of Finance and Economic Planning | Salvatore Garang Mabiordit |
| Minister of Foreign Affairs and International Cooperation | Nhial Deng Nhial |
| Minister of Gender, Social Welfare and Religious Affairs | Awut Deng Acuil |
| Minister of General Education and Instruction | Deng Deng Hoc |
| Minister of Health | Dr. Riak Gai Kok |
| Minister of Higher Education, Science and Technology | Yen Oral Lam |
| Minister of Housing, Physical Planning and Environment | Dr Lado Gore |
| Minister of Humanitarian Affairs and Disaster Management | Hussein Maar Nyot |
| Minister of Information and Broadcasting | Michael Makuei Lueth |
| Minister of Internal Affairs | Micheal Chiengjiek |
| Minister of Irrigation and Water Resources | Sophia Pal Gai |
| Minister of Justice | Paulino Wanawilla |
| Minister of Labour, Public Service and Human Resource Development | James Hoth Mai |
| Minister of National Security | Obote Mamur Mete |
| Minister of Parliamentary Affairs | Peter Bashir Bande |
| Minister of Petroleum and Mining | Ezekiel Lul Gatkuoth |
| Minister of Roads and Bridges | Rebecca Joshua Okwaci |
| Minister of Transport and Roads | John Luk Jok |
| Minister of Wildlife Conservation and Tourism | Jemma Nunu Kumba |
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1. ^The Newly Appointed Ministers, 10 July 2011 {{webarchive |url=https://web.archive.org/web/20111108235215/http://sosanews.com/2011/07/13/the-newly-appointed-ministers-or-caretakers/ |date=November 8, 2011 }}
2. ^{{cite web|url=http://www.africanews.com/2016/07/23/south-sudan-minister-taban-deng-gai-replaces-reik-machar-as-vice-president/|title=South Sudanese minister replaces 'missing' Riek Machar as vice president - Africanews|first=|last=AfricaNews|date=23 July 2016|work=africanews.com|accessdate=19 November 2016}}