“Crotonyl-CoA carboxylase/reductase”的意思、由来-开放百科全书

词条

Crotonyl-CoA carboxylase/reductase

释义

References
External links

{{Infobox enzyme
| Name = Crotonyl-CoA carboxylase/reductase
| EC_number = 1.3.1.85
| CAS_number =
| IUBMB_EC_number = 1/3/1/85
| GO_code =
| image = 4y0k.jpg
| width = 270
| caption = Crotonyl-CoA carboxylase/reductase tetramer, Streptomyces sp. NRRL 2288
}}Crotonyl-CoA carboxylase/reductase ({{EC number|1.3.1.85}}, CCR, crotonyl-CoA reductase (carboxylating)) is an enzyme with systematic name (2S)-ethylmalonyl-CoA:NADP⁺ oxidoreductase (decarboxylating).^[1]^[2] This enzyme catalyses the following chemical reaction

(2S)-ethylmalonyl-CoA + NADP⁺ (E)-but-2-enoyl-CoA + CO₂ + NADPH + H⁺

The reaction is catalysed in the reverse direction.

References

1. ^{{cite journal | vauthors = Erb TJ, Berg IA, Brecht V, Müller M, Fuchs G, Alber BE | title = Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 104 | issue = 25 | pages = 10631–6 | date = June 2007 | pmid = 17548827 | pmc = 1965564 | doi = 10.1073/pnas.0702791104 }}
2. ^{{cite journal | vauthors = Erb TJ, Brecht V, Fuchs G, Müller M, Alber BE | title = Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 106 | issue = 22 | pages = 8871–6 | date = June 2009 | pmid = 19458256 | pmc = 2689996 | doi = 10.1073/pnas.0903939106 }}

External links

{{MeshName|Crotonyl-CoA+carboxylase/reductase}}

{{CH-CH oxidoreductases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{DEFAULTSORT:Crotonyl-CoA carboxylase reductase}}

1 : EC 1.3.1

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