| 词条 | Desmond G. Higgins |
| 释义 |
| name = Des Higgins | birth_name = Desmond Gerard Higgins | image = Des Higgins ISMB 2015.jpg | image_size = | alt = | caption = Des Higgins speaking at the ISMB conference in 2015. | birth_date = {{birth date and age|1959|07|17}}[1] | birth_place = | other_names = | residence = | citizenship = | nationality = | fields = {{Plainlist|
| workplaces = {{Plainlist|
| patrons = | alma_mater = Trinity College, Dublin (PhD) | thesis_title = A numerical taxonomy of the Pterygote insects | thesis_url = http://search.proquest.com/docview/301410442 | thesis_year = 1988 | doctoral_advisor = | academic_advisors = Paul M. Sharp[2][3] | doctoral_students = | notable_students = | known_for = {{Plainlist|
| influences = | influenced = | awards = {{Plainlist|
}} | website = {{Plainlist|
| footnotes = | spouse = | children = }}Desmond Gerard Higgins is a Professor of Bioinformatics at University College Dublin,[2][10][11][12] widely known for CLUSTAL,[13] a series of computer programs for performing multiple sequence alignment. According to Nature, Higgins papers describing CLUSTAL[6][7] are among the top ten most highly cited scientific papers of all time.[14][15][16] EducationHiggins was educated at Trinity College, Dublin[23] where he was awarded a PhD in 1988 for research on numerical taxonomy of Pterygote insects.[17] ResearchResearch in the Higgins laboratory[18] focusses on developing new bioinformatics and statistical tools for evolutionary biology. The CLUSTAL program for multiple sequence alignment has been developed in the Higgins lab and the T-Coffee software was initially developed in the lab with by Cedric Notredame. Multivariate statistics are used to analyse microarray data sets and molecular evolution such as the evolution of promoters, introns and non-coding RNA.[10][19] Awards and honoursHiggins was elected a Fellow of the International Society for Computational Biology (ISCB) in 2015.[20] In 2018, Higgins received the Benjamin Franklin Award for open access in the life sciences.[9] References1. ^{{LCAuth|no2001006610|Des Higgins||}} {{ISCB Fellows}}{{Authority control}}{{DEFAULTSORT:Higgins, Desmond Gerard}}2. ^{{cite web|url=https://academictree.org/compbio/peopleinfo.php?pid=58294|website=academictree.org|title=Des Higgins, PhD: Computational Biology Tree|deadurl=yes|archiveurl=https://web.archive.org/web/20170714003201/https://academictree.org/compbio/peopleinfo.php?pid=58294|archivedate=2017-07-14|df=}} 3. ^{{cite journal|last1=Sharp|first1=Paul M.|last2=Cowe|first2=Elizabeth|last3=Higgins|first3=Desmond G.|authorlink3=Desmond G. Higgins|last4=Shields|first4=Denis C.|last5=Wolfe|first5=Kenneth H.|authorlink5=Kenneth H. Wolfe|last6=Wright|first6=Frank|title=Codon usage patterns in Escherichia coli, Bacillus subtilis, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Drosophila melanogaster and Homo sapiens; a review of the considerable within-species diversity|journal=Nucleic Acids Research|volume=16|issue=17|year=1988|pages=8207–8211|issn=0305-1048|doi=10.1093/nar/16.17.8207|pmid=3138659 |pmc=338553}} 4. ^{{cite journal|last1=Higgins|first1=Desmond G.|last2=Sharp|first2=Paul M.|authorlink2=Paul M. Sharp|title=CLUSTAL: a package for performing multiple sequence alignment on a microcomputer|journal=Gene|volume=73|issue=1|year=1988|pages=237–244|doi=10.1016/0378-1119(88)90330-7|pmid=3243435}} 5. ^{{cite journal|last1=Higgins|first1=Desmond G.|last2=Sharp|first2=Paul M.|authorlink2=Paul M. Sharp|title=Fast and sensitive multiple sequence alignments on a microcomputer|journal=Bioinformatics|volume=5|issue=2|year=1989|pages=151–153|doi=10.1093/bioinformatics/5.2.151|pmid=2720464}} 6. ^1 {{Cite journal | last1 = Thompson | first1 = J. D. | last2 = Gibson | first2 = T. J. | last3 = Plewniak | first3 = F. | last4 = Jeanmougin | first4 = F. | last5 = Higgins | first5 = D. G. | title = The CLUSTAL_X windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools | journal = Nucleic Acids Research | volume = 25 | issue = 24 | pages = 4876–4882 | year = 1997 | pmid = 9396791 | pmc = 147148 | doi=10.1093/nar/25.24.4876}} 7. ^1 {{Cite journal | last1 = Thompson | first1 = J. D. | last2 = Higgins | first2 = D. G. | last3 = Gibson | first3 = T. J. | title = CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice | journal = Nucleic Acids Research | volume = 22 | issue = 22 | pages = 4673–4680 | year = 1994 | pmid = 7984417 | pmc = 308517 | doi=10.1093/nar/22.22.4673}} 8. ^1 {{Cite journal | doi = 10.1006/jmbi.2000.4042| pmid = 10964570| title = T-coffee: A novel method for fast and accurate multiple sequence alignment| journal = Journal of Molecular Biology| volume = 302| issue = 1| pages = 205–17| year = 2000| last1 = Notredame | first1 = C. D. | last2 = Higgins | first2 = D. G. | last3 = Heringa | first3 = J. }} 9. ^1 {{cite web|title=Benjamin Franklin Award - Bioinformatics.org|url=https://www.bioinformatics.org/franklin/|website=www.bioinformatics.org|accessdate=16 March 2018|language=en}} 10. ^1 {{cite web|archiveurl=https://web.archive.org/web/20150405025534/http://www.ucd.ie/conway/research/researchers/conwayfellowsa-z/professordeshiggins|archivedate=2015-04-05|url=http://www.ucd.ie/conway/research/researchers/conwayfellowsa-z/professordeshiggins|publisher=University College Dubin|location=Dublin|title=Professor Desmond Gerard Higgins B.A.(Mod), PhD.}} 11. ^{{cite web|archiveurl=https://web.archive.org/web/20141214110940/http://www.bioinf.ucd.ie/|archivedate=2014-12-14|url=http://www.bioinf.ucd.ie|title=Des Higgins laboratory|publisher=University College Dublin|deadurl=yes|df=}} 12. ^{{EuropePMC|ORCID=0000-0002-3952-3285}} 13. ^{{YouTube|id=IQkOK3dsWs4|title=Des Higgins: Visualizing Multiple Sequence Alignments}}, Broad Institute 14. ^{{Cite journal | doi = 10.1038/514550a| pmid = 25355343| title = The top 100 papers: Nature explores the most-cited research of all time| journal = Nature| volume = 514| issue = 7524| pages = 550–3| year = 2014| last1 = Van Noorden | first1 = R. | last2 = Maher | first2 = B. | last3 = Nuzzo | first3 = R. }} 15. ^{{cite web|archiveurl=https://web.archive.org/web/20150605122305/https://www.siliconrepublic.com/innovation/2014/10/30/irish-professor-des-higgins-in-top-10-most-cited-papers-of-all-time|archivedate=2015-06-05|url=https://www.siliconrepublic.com/innovation/2014/10/30/irish-professor-des-higgins-in-top-10-most-cited-papers-of-all-time|title=Irish professor Des Higgins in top 10 most cited papers of all time|first=Colm|last= Gorey|year=2014|publisher=siliconrepublic.com|location=Dublin}} 16. ^{{Scopus id}} 17. ^{{cite thesis |degree=PhD |first=Des|last=Higgins |title=A numerical taxonomy of Pterygote insects |publisher=Trinity College, Dublin |date=1981 |url=http://search.proquest.com/docview/301410442|oclc=842505334}} 18. ^1 2 {{Google scholar id}} 19. ^1 Des Higgins {{ORCID|0000-0002-3952-3285}} 20. ^1 {{cite web|archiveurl=https://web.archive.org/web/20150415092214/https://www.iscb.org/iscb-fellows|url=https://www.iscb.org/iscb-fellows|publisher=International Society for Computational Biology|archivedate=2015-04-15|title=ISCB Fellows}} 4 : Bioinformaticians|Living people|Fellows of the International Society for Computational Biology|1959 births |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。