DFRF may refer to:

• Dryden Flight Research Center
• Democratic Front for the Reunification of the Fatherland

• Otto Rebula
• Otto Reinwald
• Otto Reislant
• Otto, Richard
• Otto Richard Skopil, Jr.
• Otto Riethmüller
• Ottorino Enzo
• Ottorino Flaborea
• Otto R. Kierulf
• Otto, Roane County, West Virginia
• Otto Rocket
• Otto Rosenfeld (disambiguation)
• Otto Roth
• Otto Rottman
• Otto Saly Binswanger
• Otto, Sarah
• Otto Saro
• Otto Satzinger
• Otto Schade
• Otto Schick's camouflage patterns
• Otto Schindler (zoologist)
• Otto Schlemmer Building
• Otto Schmidt-Hofer
• Otto Schneider-Orelli
• Otto Schop