| 词条 | Endomorphin-1 |
| 释义 |
| ImageFile = Endomorphin 1.svg | ImageSize = 250px | IUPACName = L-Tyrosyl-L-prolyl-L-tryptophyl-L-phenylalaninamide | OtherNames = |Section1={{Chembox Identifiers | IUPHAR_ligand = 1623 | CASNo = 189388-22-5 | PubChem = 5311080e | ChemSpiderID = 4470614 | SMILES = c1ccc(cc1)C[C@@H](C(=O)N)NC(=O)[C@H](Cc2c[nH]c3c2cccc3)NC(=O)[C@@H]4CCCN4C(=O)[C@H](Cc5ccc(cc5)O)N | InChI = 1/C34H38N6O5/c35-26(17-22-12-14-24(41)15-13-22)34(45)40-16-6-11-30(40)33(44)39-29(19-23-20-37-27-10-5-4-9-25(23)27)32(43)38-28(31(36)42)18-21-7-2-1-3-8-21/h1-5,7-10,12-15,20,26,28-30,37,41H,6,11,16-19,35H2,(H2,36,42)(H,38,43)(H,39,44)/t26-,28-,29-,30-/m0/s1 | InChIKey = ZEXLJFNSKAHNFH-SYKYGTKKBN | StdInChI = 1S/C34H38N6O5/c35-26(17-22-12-14-24(41)15-13-22)34(45)40-16-6-11-30(40)33(44)39-29(19-23-20-37-27-10-5-4-9-25(23)27)32(43)38-28(31(36)42)18-21-7-2-1-3-8-21/h1-5,7-10,12-15,20,26,28-30,37,41H,6,11,16-19,35H2,(H2,36,42)(H,38,43)(H,39,44)/t26-,28-,29-,30-/m0/s1 | StdInChIKey = ZEXLJFNSKAHNFH-SYKYGTKKSA-N |Section2={{Chembox Properties | Formula = C34H38N6O5 | MolarMass = 610.703 g/mol | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} Endomorphin-1 (EM-1) (amino acid sequence Tyr-Pro-Trp-Phe-NH2) is an endogenous opioid peptide and one of the two endomorphins.[1] It is a high affinity, highly selective agonist of the μ-opioid receptor, and along with endomorphin-2 (EM-2), has been proposed to be the actual endogenous ligand of the μ-receptor.[1][2][4][3] EM-1 produces analgesia in animals and is equipotent with morphine in this regard.[4] The gene encoding for EM-1 has not yet been identified[3], and it has been suggested that endomorphins could be synthesized by an enzymatic, non-ribosomal mechanism[5]. See also
References1. ^1 {{cite book| vauthors = Bodnar RJ, Commons KG, Pfaff DW |title=Central Neural States Relating Sex and Pain|url=https://books.google.com/books?id=4KeQEC4nHSkC&pg=PA67|date=3 April 2002|publisher=JHU Press|isbn=978-0-8018-6827-6|pages=67–}} {{Neuropeptides}}{{Opioidergics}}{{biochemistry-stub}}2. ^{{cite book| vauthors = Krammer HJ, Singer MV |title=Neurogastroenterology - From the Basics to the Clinics|url=https://books.google.com/books?id=ghjN0L47QbwC&pg=PA76|date=31 May 2000|publisher=Springer Science & Business Media|isbn=978-0-7923-8757-2|pages=76–}} 3. ^1 {{cite book| vauthors = Offermanns S, Rosenthal W |title=Encyclopedia of Molecular Pharmacology|url=https://books.google.com/books?id=fGe6NDIGQpsC&pg=PA904|date=14 August 2008|publisher=Springer Science & Business Media|isbn=978-3-540-38916-3|pages=904–}} 4. ^1 {{cite book| vauthors = Brain S, Moore PK |title=Pain and Neurogenic Inflammation|url=https://books.google.com/books?id=6TNSAeTpkUMC&pg=PA28|year=1999|publisher=Springer Science & Business Media|isbn=978-3-7643-5875-4|pages=28–}} 5. ^{{cite journal | vauthors = Terskiy A, Wannemacher KM, Yadav PN, Tsai M, Tian B, Howells RD | title = Search of the human proteome for endomorphin-1 and endomorphin-2 precursor proteins | journal = Life Sciences | volume = 81 | issue = 23-24 | pages = 1593–601 | date = November 2007 | pmid = 17964607 | pmc = 2144908 | doi = 10.1016/j.lfs.2007.09.025 }} 2 : Mu-opioid agonists|Neuropeptides |
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