Arsenic and Old Lace may refer to:

• Arsenic and Old Lace (play), a 1939 play by Joseph Kesselring
  • Arsenic and Old Lace (film), a 1944 film adaptation directed by Frank Capra
  • Arsenic and Old Lace, a 1955 television adaptation for the anthology series The Best of Broadway
  • Arsenic & Old Lace, a 1962 Hallmark Hall of Fame television film
  • Arsenic and Old Lace (1969 film), an ABC Movie of the Week remake directed by Robert Scheerer

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