Gugu may refer to:

• Costinel Gugu (born 1992), Romanian footballer
• Gugu Gill (also spelt Guggu Gill), Punjabi film actor
• Gugu Mbatha-Raw (born 1983), English actress
• Gugu Liberato (born 1959), Brazilian TV presenter
• Gugu River, tributary of the Cungrea Mică River in Romania
• Gugu River (Râul Șes), tributary of the Râul Şes in Romania
• Gugu Thaypan language, Paman language spoken on the southwestern part of the Cape York Peninsula, Queensland, Australia
• Gugu Uwanh dialect, Paman language spoken on the Cape York Peninsula of Queensland, Australia
• Mount Gugu, mountain located in central Ethiopia
• Gugu, a fictional leopard character in The Magic of Oz

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