| 词条 | JZL195 |
| 释义 |
| ImageFile = JZL195 molecular structure.png | ImageSize = | IUPACName = (4-nitrophenyl) 4-[(3-phenoxyphenyl)methyl]piperazine-1-carboxylate | OtherNames = |Section1={{Chembox Identifiers | CASNo = | PubChem = | ChemSpiderID = 24655100 | SMILES = c1ccc(cc1)Oc2cccc(c2)CN3CCN(CC3)C(=O)Oc4ccc(cc4)[N+](=O)[O-] | InChI = 1/C24H23N3O5/c28-24(32-22-11-9-20(10-12-22)27(29)30)26-15-13-25(14-16-26)18-19-5-4-8-23(17-19)31-21-6-2-1-3-7-21/h1-12,17H,13-16,18H2 | InChIKey = QNYRAEKLMNDRFY-UHFFFAOYAU | StdInChI = 1S/C24H23N3O5/c28-24(32-22-11-9-20(10-12-22)27(29)30)26-15-13-25(14-16-26)18-19-5-4-8-23(17-19)31-21-6-2-1-3-7-21/h1-12,17H,13-16,18H2 | StdInChIKey = QNYRAEKLMNDRFY-UHFFFAOYSA-N |Section2={{Chembox Properties | Formula = C24H23N3O5 | MolarMass = 433.457 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}JZL195 is a potent inhibitor of both fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), the primary enzymes responsible for degrading the endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively.[1] See also
References1. ^{{cite journal | vauthors = Long JZ, Nomura DK, Vann RE, Walentiny DM, Booker L, Jin X, Burston JJ, Sim-Selley LJ, Lichtman AH, Wiley JL, Cravatt BF | title = Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 106 | issue = 48 | pages = 20270–5 | date = December 2009 | pmid = 19918051 | pmc = 2787168 | doi = 10.1073/pnas.0909411106 }} {{Cannabinoids}}{{Cannabinoid-stub}} 4 : Carbamates|Piperazines|Nitrobenzenes|Cannabinoids |
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