| 词条 | LETM1-like protein family |
| 释义 |
| Symbol = LETM1 | Name = LETM1 | image = | width = | caption = | Pfam = PF07766 | Pfam_clan = | InterPro = IPR011685 | SMART = | PROSITE = | MEROPS = | SCOP = | TCDB = 8.A.20 | OPM family = | OPM protein = | CAZy = | CDD = }} LETM1-like is a family of evolutionarily related proteins. This is a group of mainly hypothetical eukaryotic proteins. Putative features found in LETM1, such as a transmembrane domain and a CK2 and PKC phosphorylation site,[1] are relatively conserved throughout the family. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans.[1] A member of this family, [https://www.uniprot.org/uniprot/P91927 SWISSPROT], is known to be expressed in the mitochondria of Drosophila melanogaster,[2] suggesting that this may be a group of mitochondrial proteins. ExamplesHuman gene encoding members of this family include:
References1. ^1 {{cite journal |vauthors=Endele S, Fuhry M, Pak SJ, Zabel BU, Winterpacht A | title = LETM1, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, flanks the Wolf-Hirschhorn syndrome (WHS) critical region and is deleted in most WHS patients | journal = Genomics | volume = 60 | issue = 2 | pages = 218–25 |date=September 1999 | pmid = 10486213 | doi = 10.1006/geno.1999.5881 | url = }} {{InterPro content|IPR011685}}2. ^{{cite journal |vauthors=Caggese C, Ragone G, Perrini B, Moschetti R, De Pinto V, Caizzi R, Barsanti P | title = Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database | journal = Mol. Gen. Genet. | volume = 261 | issue = 1 | pages = 64–70 |date=February 1999 | pmid = 10071211 | doi = 10.1007/s004380050942| url = }} 1 : Protein families |
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