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词条 Markus Rüegg
释义

  1. Life

  2. Work

  3. Awards and honors

  4. Notable publications

  5. External links

  6. References

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Markus Rüegg is a Swiss neurobiologist and professor at the Biozentrum of the University of Basel.

Life

Markus Rüegg studied biochemistry at the University of Zurich and graduated with a PhD in the field of Neurobiology. In 1989 he went as a postdoctoral fellow to conduct research at the Department of Neurobiology at Stanford University School of Medicine.[1] In 1992 he was appointed as Assistant Professor to the Biozentrum, University of Basel. Since 1998 he is a Professor of Neurobiology and teaches and conducts research at the Biozentrum of the University of Basel.[2]

Work

Rüegg studies the molecular processes important for the formation and function of the neuromuscular system. A major part of his investigations involve the characterization of the extracellular and intracellular signaling pathways. Markus Rüegg has successfully developed new approaches for the therapy of merosin-deficient congenital muscular dystrophy, a serious genetic disease.[3] In addition, his research group has recently demonstrated that the multi-protein complex mTORC1 is an important regulator of muscle growth and autophagy, a cellular self-cleaning process.[4] These findings may help to counteract pathological muscle degradation and to develop new therapy strategies.

Awards and honors

  • 2000 Robert Bing Prize of the Swiss Academy of Medical Sciences[5]
  • 2013 Chairperson, Scientific Advisory Board of the “ Swiss Foundation for Research on Muscle Diseases ” (SSEM)
  • 2000 - 2007 Council Member of the der Swiss Society for Neuroscience[6]
  • 2014 Member of the Research Committee of the European Neuromuscular Centre (ENMC)[7]

Notable publications

Full publication list[8]

  • Ruegg, M.A., Tsim, K.W., Horton, S.E., Kröger, S., Escher, G., Gensch, E.M., and McMahan, U.J. (1992). The agrin gene codes for a family of basal lamina proteins that differ in function and distribution. Neuron 8, 691-699. {{PMID|1314621}}
  • Moll, J., Barzaghi, P., Lin, S., Bezakova, G., Lochmuller, H., Engvall, E., Muller, U., and Ruegg, M.A. (2001). An agrin minigene rescues dystrophic symptoms in a mouse model for congenital muscular dystrophy. Nature 413, 302-307. {{PMID|11565031}}
  • Bentzinger, C.F., Romanino, K., Cloetta, D., Lin, S., Mascarenhas, J.B., Oliveri, F., Xia, J., Casanova, E., Costa, C.F., Brink, M., Zorzato, F., Hall, M.N., and Rüegg, M.A. (2008). Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metab 8, 411-424. {{PMID|19046572}}
  • Meinen, S., Lin, S., Thurnherr, R., Erb, M., Meier, T., and Ruegg, M.A. (2011). Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice. EMBO Mol Med 3, 465-479. {{PMID|21674808}}
  • Castets, P., Lin, S., Rion, N., Di Fulvio, S., Romanino, K., Guridi, M., Frank, S., Tintignac, L.A., Sinnreich, M., and Ruegg, M.A. (2013). Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy. Cell Metab 17, 731-744. {{PMID|23602450}}

External links

  • {{Official website|http://www.biozentrum.unibas.ch/research/groups-platforms/overview/unit/rueegg/}}

References

1. ^Former lab member stanford.com. Retrieved 2014-07-09.
2. ^Curriculum Vitae biozentrum.ch. Retrieved 2014-07-09.
3. ^Restoration of autophagy as a new strategy for the treatment of congenital muscular dystrophies fsrmm.ch. Retrieved 2014-07-09.
4. ^Uncleaned Cells Mean Weak Muscles innovations-report.com. Retrieved 2014-09-07.
5. ^Synopsis der PreisträgerInnen des Robert-Bing-Preises {{webarchive|url=https://web.archive.org/web/20140714200623/http://www.samw.ch/dms/de/Forschung/Synopsen/Synopsis_Robert-Bing.pdf |date=2014-07-14 }} samw.ch. Retrieved 2014-07-14.
6. ^Wissenschaftlicher Beirat fsrmm.ch. Retrieved 2014-07-14.
7. ^ENMC Member and Partner Organisations enmc.org. Retrieved 2014-07-09.
8. ^{{cite web|url=http://www.biozentrum.unibas.ch/research/groups-platforms/publications/unit/rueegg/ |title=Publication list |publisher=Biozentrum.unibas.ch |date= |accessdate=2014-07-09}}
{{Authority control}}{{DEFAULTSORT:Ruegg, Markus}}

7 : Living people|People from Zürich|Stanford University alumni|University of Basel faculty|University of Basel alumni|Biozentrum University of Basel|Year of birth missing (living people)

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