“Phenylalanine N-monooxygenase”的意思、由来-开放百科全书

词条

Phenylalanine N-monooxygenase

释义

References
External links

{{Infobox enzyme
| Name = Phenylalanine N-monooxygenase
| EC_number = 1.14.13.124
| CAS_number =
| IUBMB_EC_number = 1/14/13/124
| GO_code =
| image =
| width =
| caption =
}}Phenylalanine N-monooxygenase ({{EC number|1.14.13.124}}, phenylalanine N-hydroxylase, CYP79A2) is an enzyme with systematic name L-phenylalanine,NADPH:oxygen oxidoreductase (N-hydroxylating).^[1] This enzyme catalyses the following chemical reaction

L-phenylalanine + 2 O₂ + 2 NADPH + 2 H⁺ (E)-phenylacetaldoxime + 2 NADP⁺ + CO₂ + 3 H₂O (overall reaction)

(1a) L-phenylalanine + O₂ + NADPH + H⁺ N-hydroxy-L-phenylalanine + NADP⁺ + H₂O:

(1b) N-hydroxy-L-phenylalanine + O₂ + NADPH + H⁺ N,N-dihydroxy-L-phenylalanine + NADP⁺ + H₂O

(1c) N,N-dihydroxy-L-phenylalanine (E)-phenylacetaldoxime + CO₂ + H₂O

Phenylalanine N-monooxygenase is a heme-thiolate protein (P-450).

References

1. ^{{cite journal | vauthors = Wittstock U, Halkier BA | title = Cytochrome P450 CYP79A2 from Arabidopsis thaliana L. Catalyzes the conversion of L-phenylalanine to phenylacetaldoxime in the biosynthesis of benzylglucosinolate | journal = The Journal of Biological Chemistry | volume = 275 | issue = 19 | pages = 14659–66 | date = May 2000 | pmid = 10799553 | doi = 10.1074/jbc.275.19.14659 }}

External links

{{MeshName|Phenylalanine+N-monooxygenase}}

1 : EC 1.14.13

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