“Unsaturated chondroitin disaccharide hydrolase”的意思、由来-开放百科全书

词条

Unsaturated chondroitin disaccharide hydrolase

释义

References
External links

{{Infobox enzyme
| Name = Unsaturated chondroitin disaccharide hydrolase
| EC_number = 3.2.1.180
| CAS_number =
| IUBMB_EC_number = 3/2/1/180
| GO_code =
| image =
| width =
| caption =
}}Unsaturated chondroitin disaccharide hydrolase ({{EC number|3.2.1.180}}, UGL, unsaturated glucuronyl hydrolase) is an enzyme with systematic name beta-D-4-deoxy-Delta4-GlcAp-(1->3)-beta-D-GalNAc6S hydrolase.^[1]^[2] This enzyme catalyses the following chemical reaction

beta-D-4-deoxy-Delta4-GlcAp-(1->3)-beta-D-GalNAc6S + H₂O 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine-6-O-sulfate

The enzyme releases 4-deoxy-4,5-didehydro D-glucuronic acid or 4-deoxy-4,5-didehydro L-iduronic acid from chondroitin disaccharides, hyaluronan disaccharides and heparin disaccharides.

References

1. ^{{cite journal | vauthors = Maruyama Y, Nakamichi Y, Itoh T, Mikami B, Hashimoto W, Murata K | title = Substrate specificity of streptococcal unsaturated glucuronyl hydrolases for sulfated glycosaminoglycan | journal = J. Biol. Chem. | volume = 284 | issue = 27 | pages = 18059–69 | date = July 2009 | pmid = 19416976 | pmc = 2709336 | doi = 10.1074/jbc.M109.005660}}
2. ^{{cite journal | vauthors = Nakamichi Y, Maruyama Y, Mikami B, Hashimoto W, Murata K | title = Structural determinants in streptococcal unsaturated glucuronyl hydrolase for recognition of glycosaminoglycan sulfate groups | journal = J. Biol. Chem. | volume = 286 | issue = 8 | pages = 6262–71 | date = February 2011 | pmid = 21147778 | pmc = 3057837 | doi = 10.1074/jbc.M110.182618 }}

External links

{{MeshName|Unsaturated+chondroitin+disaccharide+hydrolase}}

1 : EC 3.2.1

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