| 词条 | Ciraparantag | |||||||||||||||||||||||
| 释义 |
| drug_name = | IUPAC_name = N,N′-(1,4-Piperazinediyldi-3,1-propanediyl)bis[2-amino-5-[(aminoiminomethyl)amino]-, (2S,2S)-pentanamide | image = Ciraparantag.svg | alt = | caption = | pronounce = | tradename = | Drugs.com = | MedlinePlus = | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_AU_comment = | legal_CA = | legal_DE = | legal_NZ = | legal_UK = | legal_US = | legal_UN = | legal_status = Investigational | routes_of_administration = Intravenous | bioavailability = | protein_bound = | metabolism = | metabolites = | onset = 10 min | elimination_half-life = | duration_of_action = 24 hours | excretion = | CAS_number = 1438492-26-2 | ATCvet = | ATC_prefix = None | ATC_suffix = | PubChem = 71576543 | DrugBank = | ChemSpiderID = 33427375 | UNII = U2R67KV65Q | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D10868 | synonyms = PER977 N1,N1′-[Piperazine-1,4-diylbis(propane-1,3-diyl)]bis-L-argininamide | C=22 | H=48 | N=12 | O=2 | molecular_weight = | smiles = C1CN(CCN1CCCNC(=O)[C@H](CCCNC(=N)N)N)CCCNC(=O)[C@H](CCCNC(=N)N)N | StdInChI=1S/C22H48N12O2/c23-17(5-1-7-31-21(25)26)19(35)29-9-3-11-33-13-15-34(16-14-33)12-4-10-30-20(36)18(24)6-2-8-32-22(27)28/h17-18H,1-16,23-24H2,(H,29,35)(H,30,36)(H4,25,26,31)(H4,27,28,32)/t17-,18-/m0/s1 | StdInChIKey = HRDUUSCYRPOMSO-ROUUACIJSA-N }}Ciraparantag (aripazine) is a drug under investigation as an antidote for a number of anticoagulant (anti-blood clotting) drugs, including factor Xa inhibitors (rivaroxaban, apixaban and edoxaban), dabigatran, low molecular weight heparins and unfractionated heparin.[1][2] Mechanism of actionAccording to in vitro studies, the substance binds directly to anticoagulants via hydrogen bonds from or to various parts of the molecule:[1]
Chemical propertiesCiraparantag consists of two L-arginine units connected with a piperazine containing linker chain.[1] See also
References1. ^1 2 Schubert-Zsilavecz, M, Wurglics, M, Neue Arzneimittel Herbst 2015 {{de icon}} {{blood-drug-stub}}2. ^{{cite journal|pmid=26449414|year=2015|author1=Ansell|first1=J. E.|title=Universal, class-specific and drug-specific reversal agents for the new oral anticoagulants|journal=Journal of Thrombosis and Thrombolysis|doi=10.1007/s11239-015-1288-1|volume=41|pages=248–52}} 3 : Amino acid derivatives|Antidotes|Guanidines |
|||||||||||||||||||||||
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。