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词条 Dewan Singh Bhakuni
释义

  1. Biography

  2. Legacy

  3. Awards and honors

  4. Citations

  5. Selected bibliography

      Books    Articles  

  6. See also

  7. Notes

  8. References

  9. External links

{{Use dmy dates|date=May 2018}}{{Use Indian English|date=May 2018}}{{Infobox scientist
| name = Dewan Singh Bhakuni
| image =
| alt =
| caption =
| birth_date = {{Birth date|df=yes|1930|12|30}}
| birth_place = Uttar Pradesh, India
| death_date =
| death_place =
| residence =
| nationality = Indian
| fields = {{ublist | Natural product chemistry | Bioorganic chemistry }}
| workplaces = {{ublist | Central Drug Research Institute | National Botanical Research Institute | University of Concepción }}
| alma_mater = {{ublist | Allahabad University | Imperial College London | University of London }}
| doctoral_advisor = {{ublist | Sir Derek Barton }}
| doctoral_students =
| known_for = Studies on biogenesis of alkaloids
| awards = {{ublist | 1975 Shanti Swarup Bhatnagar Prize | 1988 Ranbaxy Research Award | 1989 Sir C. V. Raman Award | 2000 Acharya P. C. Ray Memorial Award }}
}}Dewan Singh Bhakuni (born 1930) is an Indian natural product chemist, stereochemist and a former director general-grade scientist of the Central Drug Research Institute.[1] He is known for his researches on the biogenesis of alkaloids[2] and is an elected fellow of the Indian Academy of Sciences,[3] the National Academy of Sciences, India[4] and the Indian National Science Academy.[5] The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 1975, for his contributions to chemical sciences.[6]

Biography

D. S. Bhakuni, born on 30 December 1930 in the Indian state of Uttar Pradesh, graduated in chemistry from Allahabad University and completed his master's degree at the same institution.[5] He started his career in 1958 as a teaching faculty but a year later, joined Central Drug Research Institute (CDRI), Lucknow and worked there for three years. His next move was to National Botanical Research Institute in 1962 but later went to the UK to pursue his doctoral studies. He secured a Phd in 1965 from the University of London under the guidance of Sir Derek Barton of Imperial College London, a renowned organic chemist and 1969 Nobel laureate; his thesis being Studies in alkaloid biosynthesis.[7] He would also receive the degree of Doctor of Science from London University in 1978. Returning to India, he joined CDRI in 1965 where he spent the rest of his official career till his superannuation in 1990 as a director general-grade scientist. In between, he had a stint at University of Concepción, Chile as a visiting professor. Post-retirement, he was selected as an emeritus scientist by the Council of Scientific and Industrial Research.[5]

Legacy

Bhakuni, during the course of his active researches, studied the structure and stereochemistry of several indigenous plants and synthesized them for finding out the biologically active compounds; his work on the biogenesis of alkaloids was based on these examinations.[8] These studies are known to be pioneering studies on alkaloid biosynthesis and he developed a new methodology for determining the absolute configuration of alkaloids.[5] Thus, he was able to identify the anti-cancer, anti-leishmanial, anti-viral and anti-allergic properties of a number of plants through mass spectrometric and Nuclear magnetic resonance spectroscopy techniques.[5]

Bhakuni has documented his researches in a book, Bioactive Marine Natural Products[9] and over 300 articles published in peer-reviewed journals.{{Refn|group=note|Please see Selected bibliography section}} His writings have been cited by several authors{{Refn|group=note|Please see Citations section}} and he has mentored 40 doctoral scholars in their studies. A multidisciplinary program, under the title, Bioactive Substances from Indian Ocean was initiated by him during his days at the Central Drug Research Institute which is still active. He is a former president of the Indian Chemical Society (1996–97) and the Sectional Committee of Indian Science Congress Association (1994) and sat in the council of the Indian National Sciences Academy from 1982 to 1984.[5]

Awards and honors

The Council of Scientific and Industrial Research awarded Bhakuni the Shanti Swarup Bhatnagar Prize, one of the highest Indian science awards, in 1975.[10] A University Grants Commission National Lecturer (1982), he received the Ranbaxy Research Award in 1988 and Sir C. V. Raman Award in 1989.[5] He is also a recipient of Acharya P. C. Ray Memorial Award which he received in 2000. He has delivered a number of award orations; Platinum Jubilee Lecture of Indian Science Congress Association (1993) and Dr R. C. Shah Memorial Lecture of Bombay University (1993) are some of the notable ones among them.[5] He is an elected fellow of all the three major Indian science academies, Indian National Science Academy, Indian Academy of Sciences[5] and the National Academy of Sciences, India.[4]

Citations

  • {{cite book|author=M. F. Grundon|title=The Alkaloids|date=January 1983|publisher=Royal Society of Chemistry|isbn=978-0-85186-367-2|pages=40–}}
  • {{cite book|author=R. B. Herbert|title=Biosynthesis|date=31 March 1989|publisher=Royal Society of Chemistry|isbn=978-0-85186-553-9|pages=220–}}
  • {{cite book|title=Chemistry and Pharmacology|date=26 July 1996|publisher=Academic Press|isbn=978-0-08-086572-0|pages=334–}}
  • {{cite book|author1=Dewan S. Bhakuni|author2=D.S. Rawat|title=Bioactive Marine Natural Products|date=30 June 2006|publisher=Springer|isbn=978-1-4020-3484-8|pages=101–}}
  • {{cite book|author1=Dewan S. Bhakuni|author2=D.S. Rawat|title=Bioactive Marine Natural Products|date=30 June 2006|publisher=Springer|isbn=978-1-4020-3484-8|pages=234–}}
  • {{cite book|author=Guenter Grethe|title=The Chemistry of Heterocyclic Compounds, Isoquinolines|date=15 September 2009|publisher=John Wiley & Sons|isbn=978-0-470-18862-0|pages=379–}}
  • {{cite book|author1=Heiz Ellenberg|author2=Karl Esser|author3=Klaus Kubitzki, Eberhard Schnepf, Hubert Ziegler|title=Progress in Botany/Fortschritte der Botanik: Morphology · Physiology · Genetics Taxonomy · Geobotany / Morphologie · Physiologie · Genetik Systematik · Geobotanik|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-3-642-68297-1|pages=98–}}
  • {{cite book|author=John Glasby|title=Encyclopedia of the Alkaloids|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-1-4615-9322-5|pages=101–}}
  • {{cite book|author=S.W. Pelletier|title=Alkaloids: Chemical and Biological Perspectives|date=22 October 2013|publisher=Elsevier|isbn=978-1-4832-8784-3|pages=150–}}

Selected bibliography

Books

  • {{Cite book |title=Bioactive Marine Natural Products |last=Bhakuni |first=Dewan S. |last2=Rawat |first2=D. S. |publisher=Springer Netherlands |year=2006 |isbn=978-1-4020-3472-5}}

Articles

  • {{Cite journal |author1=Dewan S. Bhakuni |author2=Awadhesh N. Singh |author3=Sudha Jain |title=Biosynthesis of isotetrandrine |journal=Tetrahedron |publication-date=1980 |volume=36 |issue=14 |pages=2149–2151 |doi=10.1016/0040-4020(80)80107-4}}
  • {{Cite journal |author1=PP Gupta |author2=RC Srimal |author3=K Avasthi |author4=N Garg |author5=T Chandra |author6=DS Bhakuni |title=Antiallergic activity of alkyl substituted pyrazolo [3, 4-d] pyrimidine (compound 88-765). |journal=Indian journal of experimental biology |publication-date=1995 |volume=33 |issue=1 |pages=38–40 |pmid=9135673}}
  • {{Cite journal |vauthors=Biswas S, Sharma S, Saroha A, Bhakuni DS, Malhotra R, Zahur M, Oellerich M, Das HR, Asif AR |title=Identification of novel autoantigen in the synovial fluid of rheumatoid arthritis patients using an immunoproteomics approach |journal=PLoS ONE |publication-date=2013 |doi=10.1371/journal.pone.0056246|bibcode=2013PLoSO...856246B}}
  • {{Cite journal |vauthors=Sharma S, Ghosh S, Singh LK, Sarkar A, Malhotra R, Garg OP, Singh Y, Sharma RS, Bhakuni DS, Das TK, Biswas S |title=Identification of autoantibodies against transthyretin for the screening and diagnosis of rheumatoid arthritis |journal=PLoS ONE |publication-date=2014 |doi=10.1371/journal.pone.0093905|bibcode=2014PLoSO...993905S }}
  • {{Cite journal |vauthors=Kumar P, Bhakuni DS, Rastogi S |title=Diagnosis of Chlamydia trachomatis in patients with reactive arthritis and undifferentiated spondyloarthropathy |journal=a |publication-date=2014 |volume=8 |issue=5 |pages=648–654 |doi=10.3855/jidc.3644}}

See also

  • Sir Derek Barton
{{portal|India|Chemistry}}

Notes

1. ^{{Cite web |url=http://www.nasi.nic.in/Lucknow%20Chapter.htm |title=Popular Science Lecture on "Drug Discovery" |date=2016 |publisher=National Academy of Sciences, India}}
2. ^{{Cite web |url=http://ssbprize.gov.in/content/Detail.aspx?AID=398 |title=Brief Profile of the Awardee |date=2016 |publisher=Shanti Swarup Bhatnagar Prize |access-date=12 November 2016}}
3. ^{{Cite web |url=http://www.ias.ac.in/describe/fellow/Bhakuni,_Dr_Dewan_Singh |title=Fellow profile |date=2016 |publisher=Indian Academy of Sciences |access-date=12 November 2016}}
4. ^{{Cite web|url=http://www.nasi.org.in/fellows.asp?RsFilter=B |title=NASI Fellows |date=2016 |publisher=National Academy of Sciences, India |deadurl=yes |archiveurl=https://web.archive.org/web/20150717005033/http://www.nasi.org.in/fellows.asp?RsFilter=B |archivedate=2015-07-17 |df= }}
5. ^{{Cite web |url=http://insaindia.res.in/detail.php?id=N79-0071 |title=Indian fellow |date=2016 |publisher=Indian National Science Academy |access-date=12 October 2016}}
6. ^{{cite web | url=http://ssbprize.gov.in/Content/AwardeeList.aspx | title=View Bhatnagar Awardees | publisher=Shanti Swarup Bhatnagar Prize | date=2016 | accessdate=12 November 2016}}
7. ^{{Cite web |url=https://spiral.imperial.ac.uk/handle/10044/1/7139/browse?type=author&order=ASC&rpp=20&value=Bhakuni%2C+Dewan+Singh |title=Studies in alkaloid biosynthesis |date=2016 |publisher=University of London}}
8. ^{{cite web | url=http://www.csirhrdg.res.in/ssb.pdf | title=Handbook of Shanti Swarup Bhatnagar Prize Winners | publisher=Council of Scientific and Industrial Research | date=1999 | accessdate=5 October 2016 | pages=34}}
9. ^{{Cite book |url=https://www.amazon.com/Bioactive-Marine-Natural-Products-Bhakuni/dp/1402034725/ref=sr_1_1?s=books&ie=UTF8&qid=1479223682&sr=1-1 |title=Bioactive Marine Natural Products |last=Dewan S. Bhakuni, D.S. Rawat |publisher=Springer |year=2005 |isbn=978-1402034725 |page=382}}
10. ^{{cite web | url=http://www.csir.res.in/External/Heads/career/award/BPRIZE/CHEMICAL_SCIENCES.htm | title=Chemical Sciences | publisher=Council of Scientific and Industrial Research | date=2016 | accessdate=7 November 2016 | deadurl=yes | archiveurl=https://web.archive.org/web/20120912012851/http://www.csir.res.in/external/heads/career/award/BPRIZE/CHEMICAL_SCIENCES.htm | archivedate=12 September 2012 | df= }}

References

{{reflist}}

External links

  • {{Cite book |url=http://rushim.ru/books/biochemie/bioactive-marine-natural-products.pdf |title=Bioactive Marine Natural Products |last=D.S. Bhakuni, D.S. Rawat |publisher=Springer |work=Full text |publication-place=2005}}
  • {{Cite web |url=http://www.cdriindia.org/Awards.htm |title=Awards and Honors |date=2016 |publisher=Central Drug Research Institute}}
{{SSBPST recipients in Chemical Science}}{{authority control}}{{DEFAULTSORT:Bhakuni, Dewan Singh}}

15 : Recipients of the Shanti Swarup Bhatnagar Award in Chemical Science|1930 births|Scientists from Uttar Pradesh|Indian organic chemists|Indian scientific authors|Alumni of the University of London|Academics of Imperial College London|University of Concepción faculty|Council of Scientific and Industrial Research|Fellows of the Indian Academy of Sciences|Fellows of the Indian National Science Academy|Fellows of The National Academy of Sciences, India|University of Allahabad alumni|Living people|20th-century Indian chemists

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