“FERM and PDZ domain containing 2”的意思、由来-开放百科全书

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FERM and PDZ domain containing 2

释义

Function
References
Further reading

FERM and PDZ domain containing 2 is a protein that in humans is encoded by the FRMPD2 gene.

^[1]

Function

This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants.

References

1. ^{{cite web| title = Entrez Gene: FERM and PDZ domain containing 2| url = https://www.ncbi.nlm.nih.gov/gene/143162| accessdate = 2017-09-05}}

{{cite journal |vauthors=Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A |title=A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease |journal=Am. J. Hum. Genet. |volume=78 |issue=1 |pages=78–88 |year=2006 |pmid=16385451 |pmc=1380225 |doi=10.1086/498851 |url=}}
{{cite journal |vauthors=Stenzel N, Fetzer CP, Heumann R, Erdmann KS |title=PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells |journal=J. Cell Sci. |volume=122 |issue=Pt 18 |pages=3374–84 |year=2009 |pmid=19706687 |doi=10.1242/jcs.046854 |url=}}

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Function

References

Further reading