“1-Decanol”的意思、由来-开放百科全书

词条

1-Decanol

释义

Production
Uses
Safety
References

{{chembox
| Watchedfields = changed
| verifiedrevid = 477207517
| Reference = ^[1]
| Name = 1-Decanol
| ImageFile = 1-Decanol.png
| ImageSize = 220px
| ImageName = Skeletal formula
| ImageFile1 = 1-Decanol-3D-vdW.png
| ImageName1 = Space-filling model
| IUPACName = Decan-1-ol
| OtherNames = decyl alcohol
n-decyl alcohol
capric alcohol
epal 10
antak
agent 504
|Section1={{Chembox Identifiers
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 28903
| ChemSpiderID = 7882
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 89V4LX791F
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = C01633
| InChI = 1/C10H21OH/c1-2-3-4-5-6-7-8-9-10-11/h11H,2-10H2,1H3
| InChIKey = MWKFXSUHUHTGQN-UHFFFAOYAN
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 25363
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C10H21OH/c1-2-3-4-5-6-7-8-9-10-11/h11H,2-10H2,1H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = MWKFXSUHUHTGQN-UHFFFAOYSA-N
| CASNo_Ref = {{cascite|correct|CAS}}
| CASNo = 112-30-1
| SMILES = OCCCCCCCCCC
| PubChem = 8174
|Section2={{Chembox Properties
| Formula = C₁₀H₂₁OH
| MolarMass = 158.28 g/mol
| Density = 0.8297 g/cm³
| Viscosity = 12.048 mPa.s (@ 25 °C)
| LogP = 4.57
| MeltingPtC = 6.4
| BoilingPtC = 232.9
| Appearance = Viscous liquid
| Solubility = 37 mg/L at 20°C^[2]
|Section7={{Chembox Hazards
| FlashPtC = 108
| ExternalSDS = Oxford MSDS
}}

1-Decanol is a straight chain fatty alcohol with ten carbon atoms and the molecular formula C₁₀H₂₁OH. It is a colorless to light yellow viscous liquid that is insoluble in water and has an aromatic odor.^[3] The interfacial tension against water at 20 °C is 8.97 mN/m.

Production

Decanol can be prepared by the hydrogenation of decanoic acid, which occurs in modest quantities in coconut oil (about 10%) and palm kernel oil (about 4%). It may also be produced synthetically via the Ziegler process.

Uses

Decanol is used in the manufacture of plasticizers, lubricants, surfactants and solvents. Its ability to permeate the skin has led to it being investigated as a penetration enhancer for transdermal drug delivery.^[4]^[5]

Safety

Like other medium chain fatty alcohols, 1-decanol is able to permeate the skin which can lead to irritation.

References

1. ^Merck Index, 12th Edition, 2911.
2. ^https://pubchem.ncbi.nlm.nih.gov/compound/1-decanol
3. ^{{cite web|title=SAFETY DATA SHEET|url=http://www.fishersci.com/ecomm/servlet/msdsproxy?productName=AC219630500&productDescription=DECYL+ALCOHOL%2C+99%2B%25+50GR&catNo=AC21963-0500&vendorId=VN00032119&storeId=10652|publisher=Acros Organics|accessdate=23 April 2015}}
4. ^{{cite journal|last1=Kanikkannan|first1=N|last2=Singh|first2=Mandip|title=Skin permeation enhancement effect and skin irritation of saturated fatty alcohols|journal=International Journal of Pharmaceutics|date=November 2002|volume=248|issue=1–2|pages=219–228|doi=10.1016/S0378-5173(02)00454-4}}
5. ^{{cite journal|last1=Williams|first1=Adrian C|last2=Barry|first2=Brian W|title=Penetration enhancers|journal=Advanced Drug Delivery Reviews|date=March 2004|volume=56|issue=5|pages=603–618|doi=10.1016/j.addr.2003.10.025}}

3 : Fatty alcohols|Primary alcohols|Alkanols

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。