Tefé may refer to:

• Tefé, municipality in the state of Amazonas, Brazil
• Tefé River, river in the state of Amazonas, Brazil
• Tefé Airport, airport in Amazonas, Brazil
• Roman Catholic Territorial Prelature of Tefé, Catholic prelature in Brazil
• Tefé Holland, DC Comics fictional character
• Barão de Teffé (H-42), former Brazilian oceanographic research ship

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• 2002 Vitim event
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• 2002 Whitbread Book Awards
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• 2002 Winter Olympic Games/Skeleton
• 2002 Winter Olympic Games/Ski jumping
• 2002 Winter Olympic Games/Snowboarding