| 词条 | Bicoid 3'-UTR regulatory element |
| 释义 |
| Name = Bicoid 3'-UTR regulatory element | image = RF00551.jpg | width = 200px | caption = Stem-loop structure of the bicoid 3'-UTR regulatory element | Symbol = bcd | AltSymbols = | Rfam = RF00551 | miRBase = | miRBase_family = | RNA_type = Cis-reg | Tax_domain = Insecta | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} The bicoid 3'-UTR regulatory element is an mRNA regulatory element that controls the gene expression of the bicoid protein in fruitfly Drosophila Melanogaster. The structured RNA element consists of four domains (denoted as II, III, IV and V) in the 3'UTR of the mRNA. It is essential for the correct transport and localisation of bicoid mRNA during oocyte and embryo differentiation, which has been studied most thoroughly in the development of Drosophila melanogaster (fruitfly) larvae.[1][2][3][4] References1. ^{{cite journal |author=Macdonald PM, Struhl G |title=cis-acting sequences responsible for anterior localization of bicoid mRNA in Drosophila embryos. |journal=Nature |volume=336 |issue=6199 |pages=595–8 |year=1988 |pmid=3143913 |doi=10.1038/336595a0}} 2. ^{{cite journal |author=MacDonald PM |title=bicoid mRNA localization signal: phylogenetic conservation of function and RNA secondary structure. |journal=Development |volume=110 |issue=1 |pages=161–71 |year=1990 |pmid=2081457}} 3. ^{{cite journal |author=Seeger MA, Kaufman TC |title=Molecular analysis of the bicoid gene from Drosophila pseudoobscura: identification of conserved domains within coding and noncoding regions of the bicoid mRNA. |journal=EMBO J |volume=9 |issue=9 |pages=2977–87 |year=1990 |pmid=1975239 |pmc=552015}} 4. ^{{cite journal | last = Ehresmann C | first = C | year = 2004 | title = Secondary structure of the 3' UTR of bicoid mRNA | journal = Biochimie | volume = 86 | pages = 91–104 | doi = 10.1016/j.biochi.2004.01.002 | pmid = 15016447 | last2 = Ehresmann | first2 = C | issue = 2}} External links
3 : Cis-regulatory RNA elements|Animal developmental biology|Drosophila melanogaster genetics |
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