| 词条 | Brenner tumour | |
| 释义 |
| name = Brenner tumor | synonyms = | image = Brenner Tumor of Ovary.jpg | caption = A Brenner tumor of ovary (gross image). | pronounce = | field = Oncology | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }}Brenner tumors are an uncommon subtype of the surface epithelial-stromal tumor group of ovarian neoplasms. The majority are benign, but some can be malignant.[1] They are most frequently found incidentally on pelvic examination or at laparotomy.[2] Brenner tumours very rarely can occur in other locations, including the testes.[3] PresentationOn gross pathological examination, they are solid, sharply circumscribed and pale yellow-tan in colour. 90% are unilateral (arising in one ovary, the other is unaffected). The tumours can vary in size from less than {{convert|1|cm|in}} to {{convert|30|cm|in}}. Borderline and malignant Brenner tumours are possible but each are rare. DiagnosisHistologically, there are nests of transitional epithelial (urothelial) cells with longitudinal nuclear grooves (coffee bean nuclei) lying in abundant fibrous stroma. Also recall that the "coffee bean nuclei" are the nuclear grooves exceptionally pathognomonic to the sex cord stromal tumor, the ovarian granulosa cell tumor, with the fluid-filled spaces Call-Exner bodies between the granulosa cells.[4][5] Similar conditionsTransitional cell carcinoma is an even rarer entity, in which neoplastic transitional epithelial cells similar to transitional cell carcinoma of the bladder are seen in the ovary, without the characteristic stromal/epithelial pattern of a Brenner tumour. Histologically, Leydig cell tumors of the testes and ovarian stromal Leydig cell tumors (ovarian hyperandrogenism and virilization) both have characteristic Reinke crystals. The same crystals were also noted under high power view in Brenner tumors.[https://www.med-ed.virginia.edu/courses/path/gyn/ovary3.cfm][6] EponymIt is named for Fritz Brenner (1877–1969), a German surgeon who characterized it in 1907.[7] The term "Brenner tumor" was first used by Robert Meyer, in 1932.[8] Additional imagesReferences1. ^{{cite journal |vauthors=Marwah N, Mathur SK, Marwah S, Singh S, Karwasra RK, Arora B |title=Malignant Brenner tumour--a case report |journal=Indian J Pathol Microbiol |volume=48 |issue=2 |pages=251–2 |year=2005 |pmid=16758686 |doi=}} 2. ^{{cite journal |vauthors=Green GE, Mortele KJ, Glickman JN, Benson CB |title=Brenner tumors of the ovary: sonographic and computed tomographic imaging features |journal=J Ultrasound Med |volume=25 |issue=10 |pages=1245–51; quiz 1252–4 |year=2006 |pmid=16998096 |doi= 10.7863/jum.2006.25.10.1245|url=http://www.jultrasoundmed.org/cgi/pmidlookup?view=long&pmid=16998096 |archive-url=https://archive.today/20130415063140/http://www.jultrasoundmed.org/cgi/pmidlookup?view=long&pmid=16998096 |dead-url=yes |archive-date=2013-04-15 }} 3. ^{{cite journal |vauthors=Caccamo D, Socias M, Truchet C |title=Malignant Brenner tumor of the testis and epididymis |journal=Arch. Pathol. Lab. Med. |volume=115 |issue=5 |pages=524–7 |year=1991 |pmid=2021324 |doi=}} 4. ^{{Cite web | url=https://www.med-ed.virginia.edu/courses/path/gyn/ovary3.cfm | title=Pathology Thread}} 5. ^{{Cite journal|last=Ahr|first=A.|last2=Arnold|first2=G.|last3=Göhring|first3=U. J.|last4=Costa|first4=S.|last5=Scharl|first5=A.|last6=Gauwerky|first6=J. F.|date=July 1997|title=Cytology of ascitic fluid in a patient with metastasizing malignant Brenner tumor of the ovary. A case report|journal=Acta Cytologica|volume=41|issue=4 Suppl|pages=1299–1304|issn=0001-5547|pmid=9990262|doi=10.1159/000333524}} 6. ^{{Cite journal|last=Kuno|first=Yoshika|last2=Baba|first2=Tsuyoshi|last3=Kuroda|first3=Takafumi|last4=Teramoto|first4=Mizue|last5=Hirokawa|first5=Naoki|last6=Endo|first6=Toshiaki|last7=Saito|first7=Tsuyoshi|date=2018-06-21|title=Rare case of occult testosterone‐producing ovarian tumor that was diagnosed by selective venous hormone sampling|journal=Reproductive Medicine and Biology|volume=17|issue=4|pages=504–508|doi=10.1002/rmb2.12213|issn=1445-5781|pmc=6194242|pmid=30377407}} 7. ^{{cite journal |vauthors=Lamping JD, Blythe JG |title=Bilateral Brenner tumors: a case report and review of the literature |journal=Hum. Pathol. |volume=8 |issue=5 |pages=583–5 |year=1977 |pmid=903146 |doi=10.1016/S0046-8177(77)80117-2}} 8. ^{{cite book |author=Philipp, Elliot Elias |author2=O'Dowd, Michael J. |title=The history of obstetrics and gynaecology |publisher=Parthenon |location=Carnforth, Lancs |year=2000 |isbn=978-1-85070-040-1 |oclc= |doi= |page=586}} External links{{Medical resources| DiseasesDB = 33431 | ICD10 = | ICD9 = {{ICD9|220}} | ICDO = 9000 | OMIM = | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeshID = D001948 }}
1 : Ovarian cancer |
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