| 词条 | Cardiotrophin 1 |
| 释义 |
|Name=cardiotrophin 1 |caption= |image= |width= |HGNCid=2499 |Symbol=CTF1, CT1, CT-1 |AltSymbols= |EntrezGene=1489 |OMIM=600435 |RefSeq=NM_001330 |UniProt=Q16619 |PDB= |ECnumber= |Chromosome=16 |Arm=p |Band=11.2 |LocusSupplementaryData=-16p11.1 }} Cardiotrophin-1 (CT-1) is a cytokine. It is a cardiac hypertrophic factor of 21.5 kDa and a protein member of the IL-6 cytokine family. PathologyCT-1 is associated with the pathophysiology of heart diseases, including hypertension, myocardial infarction, valvular heart disease, and congestive heart failure. Mode of actionThe protein exerts its cellular effects by interacting with the glycoprotein 130 (gp130)/leukemia inhibitory factor receptor beta (LIFR) heterodimer. In addition, CT-1 activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes and enhances transcription factor NF-κB DNA -binding activities. CT-1 is highly expressed in the heart, skeletal muscle, prostate and ovary and to lower levels in lung, kidney, pancreas, thymus, testis and small intestine. [1] References1. ^{{Cite web|url=http://www.abcam.com/index.html?datasheet=9838|title=Recombinant human Cardiotrophin 1 protein (ab9838)|website=www.abcam.com|language=en|access-date=2017-08-09}} External links
|
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。