Cactus Jack may refer to:

• Cactus Jack (band), Serbian hard rock band
• The UK and Australian release name of the 1979 movie The Villain, starring Kirk Douglas as Cactus Jack
• A ring name of professional wrestler Mick Foley
• John Nance Garner, 32nd Vice President of the United States, who was nicknamed Cactus Jack by early political colleagues
• Jack Wells (1911–1999), Canadian sportscaster known as Cactus Jack
• "Cactus Jack" Jack Neumeier, legendary American high school football coach from Granada Hills High School, Granada Hills, California, originator of American football's spread offense.
• John Wesley `Cactus Jack' Call, (born 1923) Kansas City disc jockey killed in a car crash in January 1963, the benefit to which country stars Patsy Cline Hawkshaw Hawkins and Cowboy Copas had donated their performances in March of that year. En route back to Nashville, all three stars plus concert manager and promoter Randy Hughes were killed in the 1963 Camden, TN Piper Comanche plane crash.
• Travis Scott, an American rapper

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